帕金森病患者伴发运动并发症的研究

INVESTIGATION ON PARKINSON'S DISEASE PATIENTS WITH MOTOR COMPLICATIONS

目的探讨帕金森病(PD)患者伴发运动并发症的情绪、认知、运动功能。方法 82例原发性PD患者,采用汉密尔顿焦虑量表(HAMA14)和汉密尔顿抑郁量表(HAMD_(24))评价焦虑和抑郁情绪、简易智能状态检查量表(MMSE)和蒙特利尔认知评价量表(MoCA,北京版)评价认知功能,统一帕金森病评价量表第三部分(UPDRSⅢ)和Hoehn-Yahr分级评价病情严重程度,分析PD患者伴发运动并发症的情绪、认知、运动功能变化。结果 82例PD患者中,36例(43.90%)存在运动并发症,与不伴运动并发症的PD患者相比,伴运动并发症的PD患者病程、HAMA_(14)评分、HAMD_(24)评分、UPDRSⅢ评分、Hoehn-Yahr分期明显增高,二组间的差异有统计学意义(P<0.05),而二组的MoCA评分、MMSE评分之间的差异无统计学意义(P>0.05)。结论 PD伴发运动并发症的患者病程长,焦虑抑郁情绪较严重,运动功能较差。

Objective To explore emotion, cognitive and motor function in Parkinson＇s disease （PD） pa- tients with motor complications. Methods Totally 82 patients with primary PD were enrolled in this study. Hamilton Anxiety Rating Scale （14- item version, HAMA14） and Hamilton Depression Rating Scale （24 -item^version, HAMD24） were used to evaluate the anxiety and depression. Mini- Mental State Exami- nation （MMSE） and Montreal Cognitive Assessment {MoCA, Beijing version） were used to evaluate the cognitive function. Unified Parkinson＇s Disease Rating Scale Part Ⅲ （UPDRS Ⅲ） and Hoehn-Yahr stage were used to evaluate the severity of the disease. The emotion, cognitive and motor function in PD patients with motor complications were analyzed. Results Among 82 patients, 36（43.90%）were with motor complications. The course of disease, HAMA14 score, HAMD24 score, UPDRS m score, Hoehn-Yahr Stage were significantly higher in patients with motor complications than in those without motor complications, and there were significant differences between the two groups（P〈0.05. However,the MoCA score, MMSE score were not statistically significant（P〉0.05）. Conclusion There were longer the course of disease, more serious anxiety and depression emotion, poor motor function in PD patients with motor complications.