孕期妇女血清全氟辛烷磺酸和全氟辛酸负荷水平

Serum Loading Level of PFOA and PFOS in Pregnant Women

目的：探讨孕妇体内血清全氟辛烷磺酸（PFOS）与全氟辛酸负荷水平（PFOA）及其影响因素。方法：以人口数为权重的随机整群抽样方法获得研究对象,抽取其肘静脉血,运用高压液相色谱串联三重四级杆质谱法定量分析血清PFOS与PFOS水平,同时运用自编问卷调查影响孕妇血清PFOS与PFOS水平的可能因素。结果：共收集研究对象217名,PFOS、PFOA的检出率分别为86.18%、92.63%,187名孕妇血清中PFOS含量为0.048~14.560ng/mL,201名孕妇血清中PFOA含量为6.532~16.472ng/mL,孕妇血清PFOS水平影响因素有年龄、怀孕次数及文化程度等,孕妇血清PFOA水平影响因素有本地居住时长、子女数及文化程度等。结论：孕妇血清PFOS与PFOA中位值为2.854ng/mL、7.966ng/mL,影响因素包括年龄、怀孕次数、本地居住时长、子女数等。

Objective： To investigate the loading levels of serum perfluorooctane sulfonate （PFOS） and perfluorooctanoic acid （PFOA） in pregnant women and influencing factors. Method： The random cluster sampling method was used to obtain research subjects based on weight of population. The sub- jects＇elbow vein blood was collected and the level of serum PFOS and PFOS were quantitatively ana- lyzed by HPLC in tandem with triple quadrupole spectrometry. Meanwhile, questionnaire was used to investigate the factors that influenced the serum PFOS and PFOS level in these pregnant women. Results： A total of 217 subjects were collected, and the detection rate of PFOS and PFOA were 86. 18% and 92.63%, respectively. The serum PFOS content of 187 pregnant women was 0. 048 14. 560 μg/L, and the serum PFOA content of 201 pregnant women was 6. 532 - 16. 472 μg/L. The influence factors of serum PFOS level in pregnant women were related with age, number of pregnancies and education, and the influence factors of serum PFOA level in pregnant women were related with lo- cal residence time, the number of children and education. Conclusion： Median value of serum level of PFOS and PFOA are 2. 854 μg/L and 7. 966 μg/L, and the possible influencing factors include the age, the number of pregnancy, the length of residence, the number of children and so on.