调脂药物的不良反应及其处理措施

Adverse Effects of Lipid- lowering Agents and Corresponding Management

调脂药物应用于调整血脂以防治动脉粥样硬化已有近30年的历史,尤其是他汀类调脂药物,由于其能安全、有效地降低低密度脂蛋白胆固醇(LDL-C)、升高高密度脂蛋白胆固醇(HDL-C)、阻止脂质浸润沉积血管壁以及稳定斑块等,目前在临床应用广泛。但临床研究及临床实践均提示其存在不良反应,使其临床应用受到限制。本文通过详述调脂药物的不良反应及其处理措施,为临床医生科学合理应用该类药物提供指导建议。

For nearly three decades,lipid- lowering agents,especially statins have been widely used for regulating blood lipids,and preventing atherosclerosis for its safety and efficacy in lowering low- density lipoprotein cholesterol（ LDL-C）and elevating high- density lipoprotein cholesterol（ HDL-C）,thwarting lipids infiltration and deposition in the vascular wall and stabilizing plaques. However,the side effects of this kind of drugs have been revealed by clinical trials and applications,subsequently the application of them has been limited. This paper is a review on the adverse effects of lipid- lowering agents and corresponding treatment methods,which provide guidance to doctors to deal with these agents reasonably.