难治性高血压的相关危险因素分析

Related risk factors of refractory hypertension

目的：探讨难治性高血压的相关危险因素。方法对31例难治性高血压患者（观察组）和52例非难治性高血压患者（对照组）患者的临床资料进行回顾性分析。结果两组体质量指数、高血压病程、24 h收缩压、24 h舒张压、平均心率、脉压、估测肾小球滤过率、动态动脉硬化指数、左室肥厚和饮酒史比较差异均有显著性（P＜0．05或0．01）；多因素Logistic回归分析显示，难治性高血压与高血压病程、估测肾小球滤过率、24 h收缩压、左室肥厚和饮酒史显著相关（O R＝1．049、1．882、1．077、2．211、2．138）。结论高血压病程延长、肾小球滤过率下降、24 h收缩压升高和饮酒史均为难治性高血压的相关危险因素，临床应以此为依据，及早筛查难治性高血压的高危人群，通过针对性干预，促进病情转归。

Objective To explore the related risk factors of refractory hypertension （RH） .Methods Clin‐ical data of 31 RH patients （observation group） and 52 non‐RH ones （control group） were retrospectively analyzed .Results There were significant group differences in body mass index （BMI） ,course of hyper‐tension ,24hSBP ,24hDBP ,HR ,PP ,eGFR ,AASI ,LVH and alcohol drinking history （P〈 0 .05 or 0 .01）;multiple logistic regression analysis indicated that RH was significantly related to course of hyper‐tension ,eGFR ,24hSBP ,LVH and alcohol drinking history （OR = 1 .049 ,1 .882 ,1 .077 ,2 .21 and 2 .138） .Conclusion The related risk factors of refractory hypertension are prolonged course of hyperten‐sion ,descended eGFR ,elevated 24hSBP and alcohol drinking history ,high risk populations of refractoy hypertension should be early screened clinically on this basis in order to promote the turnover of patient＇s condition via purposeful intervention .