布鲁杆菌感染患者外周血中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值的临床意义

Clinical significance of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio of peripheral blood in patients with Brucellosis

目的探讨中性粒细胞／淋巴细胞比值（NLR）、血小板／淋巴细胞比值（PLR）在布鲁杆菌感染患者中的临床意义。方法回顾性分析2013年4月～2015年10月内蒙古医科大学附属医院收治的64例确诊的感染布鲁杆菌疾病以及同期健康体检的60名健康人群的白细胞计数、NLR及PLR结果，并通过受试者工作曲线（ROC）下面积评价各指标对布鲁杆菌疾病的诊断价值。结果64例布鲁杆菌疾病患者最常见的临床表现为疲劳乏力（24例，37．5％）、食欲不振（22例，34．4％）、关节疼痛（22例，34．4％）、肌肉痛（20例，31．3％）、发烧（12例，18．8％）及寒颤（12例，18．8％）等，偶尔伴有腹痛（4例，6．3％）、恶心（2例，3．1％）、呕吐（2例，3．1％）、便秘（2例，3．1％）等消化道不适反应。布鲁杆菌疾病患者的白细胞计数、PLR及NLR均较健康人群显著升高，差异均有统计学意义（P〈0．05）。ROC曲线分析结果表明，NLR的ROC曲线下面积最大为0．756，诊断价值较高，而白细胞计数ROC曲线下面积为0．512，PLR为0．621，血红蛋白为0．585，诊断价值较低。结论布鲁杆菌疾病患者NLR及PLR均升高，但NLR的诊断价值更高。

Objective To investigate the clinical significance of neutrophil/lymphocyte ratio （NLR） and platelet/ lymphocyte ratio （PLR） of peripheral blood in patients with Brucellosis. Methods The results of white blood cell count （WBC）, NLR, PLR of 64 patients diagnosed as Brucellosis admitted to Affiliated Hospital of Inner Mongolia Medical University from April 2013 to October 2015 and 60 healthy persons by physical examination at the same stage were analyzed retrospectively. The diagnostic value of the indexes above for the Brucellosis was evaluated through the area under the receiver operating characteristic （ROC） curve. Results The most common symptoms of 64 patients with Brucellosis were fatigue （24 cases, 37.5%）, anorexia （22 cases, 34.4%）, joint pain （22 cases, 34.4%）, myalgia （20 cases, 31.3%）, fever （12 cases, 18.8%） and chilis （12 cases, 18.8%）, occasionally accompanied by abdominal pain （4 cases, 6.3%）, nausea （2 cases, 3.1%）, vomiting （2 cases, 3.1%）, constipation （2 cases, 3.1%） and other gastrointestinal reactions. The levels of WBC, PLR and NLR in the patients with Brucellosis were higher than those of healthy persons, the differences were all statistically significant （P 〈 0.05）. The results of ROC curve analysis showed that, the highest area under ROC curve of NLR was 0.756, the diagnostic value was high, yet the area under ROC curve of WBC was 0.512, which of PLR was 0.621 and hemoglobin was 0.585, the diagnostic value was low. Conclusion The levels of NLR and PLR in the patients with Brucellosis are both increased significantly, but the diagnostic value of NLR is more higher.