甲酰肽受体2研究进展

Research progress in formyl peptide receptor 2

甲酰肽受体2(FPR2)是一种趋化物质受体,属于G蛋白偶联受体家族。FPR2不仅高表达于嗜中性粒细胞和单核/巨噬细胞,在其他多种组织细胞中也有表达。FPR2的配体可分为多肽/蛋白和脂类两大类。FPR2与不同的激动剂结合产生不同的效应。研究发现,FPR2参与多种生理和病理过程,包括防御反应、炎症、神经退行性疾病、肿瘤、糖脂代谢紊乱相关疾病等。FPR2是治疗多种疾病的潜在靶标。本文对近年来在FPR2激动剂、信号转导、生理功能和病理意义方面的研究进展作一综述。

Formyl-peptide receptor 2 （FPR2） is a chemoattractant receptor which belongs to G protein-cou- pled receptor family. It is expressed not only highly in neutrophils, monocytes and macrophages, but also in other types of cells. FPR2 ligands can be divided into two groups, peptide/proteins and lipids. Activation of FPR2 by different agonists results in agonist-specific response. FPR2 is involved in a range of physiological processes and diseases, including host defense, inflammation, neurodegenerative disorders, cancer, dysregula- tion of glucose and lipid metabolism. FPR2 is a potential therapeutic target against several kinds of diseases. Here, we review recent research progress in FPR2 agonists and signal transduction, as well as its physiological and pathological significance.