瑞舒伐他汀联合银杏叶片对脑梗死患者颈动脉粥样硬化斑块及血脂异常的影响

Effect of rosuvastatin combined with Ginkgo Biloba Leaves extract tablets on carotid atherosclerotic plaques and dyslipidemia in patients with cerebral infarction

目的观察瑞舒伐他汀联合银杏叶片对脑梗死患者颈动脉粥样硬化斑块及血脂异常的影响。方法选取脑梗死伴颈动脉粥样硬化斑块和血脂异常患者56例,采用随机数字表法将患者分为2组,每组28例。对照组患者睡前顿服瑞舒伐他汀10 mg;观察组患者睡前顿服瑞舒伐他汀10 mg,同时服用银杏叶片,每次2片,每日3次;2组患者均治疗6个月。采用颈动脉多普勒超声分别于治疗前后检测颈动脉内膜-中膜厚度(IMT)及颈动脉粥样硬化斑块,计算斑块面积和斑块总积分;采用全自动生物化学分析仪检测三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平。结果治疗前,2组患者颈动脉IMT、斑块面积、斑块总积分及TC、TG、LDL-C、HDL-C水平比较差异均无统计学意义(P>0.05)。与治疗前比较,治疗后2组患者颈动脉IMT、斑块面积、斑块总积分及TC、TG、LDL-C水平均降低(P<0.05),HDL-C水平升高(P<0.05);与对照组治疗后比较,观察组患者治疗后颈动脉IMT、斑块面积、斑块总积分及TC、TG、LDL-C水平降低,HDL-C水平升高(P<0.05)。结论瑞舒伐他汀联合银杏叶片能更好地逆转脑梗死患者颈动脉粥样硬化斑块的形成,缩小颈动脉IMT值、斑块总积分及斑块面积,降低血脂。

Objective To observe the effect of rosuvastatin combined with Ginkgo Biloba Leaves extract tablets on carotid atherosclerotic plaques and dyslipidemia in patients with cerebral infarction. Methods A total of 56 cerebral infarction patients with carotid atherosclerotic plaques and dyslipidemia were selected and randomly divided into control group（ n = 28）and observation group（ n = 28）. The patients in control group were given rosuvastatin 10 mg at bedtime（ draught）; based on this,the patients in observation group were given two Ginkgo Biloba Leaves extract tablets,three times per day; all patients were treated for six months. The carotid intima-media thickess（ IMT） and carotid atherosclerotic plaque were detected by carotid Doppler ultrasound; and then the area and score of plaque were calculated. The levels of triglyceride（ TG）,total cholesterol（ TC）,low density lipoprotein cholesterol（ LDL-C） and high density lipoprotein cholesterol（ HDL-C） were detected by automatic biochemical analyzing equipment. Results Before treatment,there was no statistic difference of the carotid IMT,plaque area,total plaque scores,TC,TG,LDL-C and HDL-C between the two groups（ P〉0. 05）. Compared with those before treatment,the carotid IMT,plaque area,total plaque scores,TC,TG and LDL-C were decreased,but the HDL-C was increased after treatment in the two groups（ P〈0. 05）. After treatment,the carotid IMT,plaque area,total plaque scores,TC,TG and LDL-C of patients in observation group were significantly lower than those in control group,but the HDL-C was higher than that in control group（ P〈0. 05）. Conclusions Rosuvastatin combined with Ginkgo Biloba Leaves extract tablets can inhibit the formation of carotid atherosclerotic plaques and decrease the IMT value,plaque area,total plaque scores and blood fat levels.