尿液血管紧张素原与IgA肾病肾脏组织病理损伤的研究

Research of urine angiotensinogen and pathological damage of kidney tissue in IgA nephropathy

目的探讨免疫球蛋白A(IgA)肾病患者尿液血管紧张素原(AGT)活性与临床及肾脏组织损伤的关系。方法 55例肾穿刺活检确诊的IgA肾病患者,分别测定其尿液AGT含量,并与临床、病理指标相比较分析。结果尿液AGT含量与24 h尿蛋白定量、肾小球、肾小管及肾间质积分呈正相关。随着病理评分的加重、尿蛋白定量的增加,尿液AGT原逐渐升高(P<0.05)。结论 IgA肾病患者尿液AGT可以反映临床及肾脏组织损伤的程度,可作为临床评估IgA肾病病情的无创指标之一。

Objective To investigate relationship between urine angiotensinogen （AGT） activity and clinical and kidney tissue damage in immune globulin A （IgA） nephropathy patients. Methods Urine AGT contents were detected in 55 renal biopsy diagnosed IgA nephropathy patients to compare and analyze with clinical and pathological indexes. Results Urine AGT content was positively correlation with 24 h urine protein content, glomerulus, kidney tubules and renal interstitium score. Increasing pathological score and urine protein content led to gradually increased urine AGT （P〈0.05）. Conclusion Urine AGT reflects clinical and kidney tissue damage in IgA nephropathy patients, and it can be taken as one of noninvasive indexes in clinical evaluation of IgA nephropathy.