摘要
乙型肝炎流行范围广,是肝硬化、肝衰竭和肝癌的重要病因,严重威胁人类健康.因乙型肝炎病毒(hepatitis B virus,HBV)特殊的复制过程中共价闭合环状DNA(covalent closed circular DNA,ccc DNA)的稳态调节和病毒特异性的免疫耐受,造成HBV慢性持续性感染,难以清除.现有的治疗大多只能抑制病毒复制,不能清除乙型肝炎表面抗原(hepatitis B surface antigen,HBs Ag)和HBV c c c D N A.乙型肝炎的"治愈"治疗是科学家一直努力的方向,其标志是HBs Ag的消失和肝细胞内HBV ccc DNA的清除.近年来,随着对HBV致病机制的深入研究和基因编辑技术的发展,乙型肝炎的"治愈"治疗已曙光初现.本文就乙型肝炎的"治愈"研究方面的进展进行简要综述.
Hepatitis B is a worldwide health problem and the main cause of liver cirrhosis,liver failure,and liver cancer.The steady state of hepatitis B virus（HBV） covalently closed circular DNA（cccDNA） in HBV infected hepatocytes and virus specific immune tolerance contribute to the chronic persistent infection and hardto-cure of hepatitis B.The presently available therapeutics for hepatitis B can control viral replication,but rarely eliminate HBV surface antigen（HBsAg） or HBV cccDNA.The ＂cure＂ of hepatitis B,which is characterized by the HBsAg loss or HBsAg seroconversion,and cccDNA clearance,has been the goal of researchers for years.In recent years,with the robust progress in understanding the HBV pathogenesis and the rapid development of gene editing technology,the ＂cure＂ of hepatitis B becomes prospective.This paper aims to summarize the potential strategies for the ＂cure＂ of hepatitis B.
出处
《世界华人消化杂志》
CAS
2016年第33期4438-4449,共12页
World Chinese Journal of Digestology
基金
国家传染病防治重大专项基金资助项目
No.2013ZX10002-001~~
