肿瘤坏死因子-α-308位点多态性与系统性红斑狼疮相关性的Meta分析

Correlation between TNF-α-308A/G polymorphism and susceptibility to systemic lupus erythematosus:a Meta-analysis

目的:研究肿瘤坏死因子(TNF)-α-308位点多态性与系统性红斑狼疮(SLE)易感性的相关性。方法:检索Pub Med、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、万方数据库,检索时间为1997年1月—2015年4月。按照纳入和排除标准收集TNF-α-308位点多态性与SLE易感性的相关性研究的文献,并对其进行质量评价,用Rev Man5.0软件进行Meta分析。结果:共纳入24篇文献,共有SLE患者4104例,健康对照5580例。对总体人群进行Meta分析,发现等位基因A与SLE相关[OR=1.68,95%CI(1.36,2.07),P<0.01];将人群按地域分层,发现TNF-α-308 A等位基因与欧洲人群[OR=2.08,95%CI(1.59,2.71),P<0.001],亚洲人群[OR=1.44,95%CI(1.04,2.01),P=0.03]SLE易感性相关。结论:欧洲人群和亚洲人群中TNF-α-308位点多态性可能与SLE易感性有关。

Objective： To investigate the correlation between tumor necrosis factor-α（TNF-α） promoter 308 A/G polymorphism and systemic lupus erythematosus（SLE） susceptibility. Methods： A comprehensive search of articles published from Jan. 1997 to Apr. 2015 was conducted in Databases of PubMed, CNKI, CBM and Wanfang. Qualified studies were included according to the criteria, and RevMan5.0 software was used for meta-analysis. Results： A total of 24 studies, including 4104 cases of SLE and 5580 healthy controls were enrolled in the current meta-analysis. In all subjects as a whole, allele A was associated with the increasing risk of SLE [OR=1.68, 95%CI（1.36, 2.07）, P〈0.01]; Regarding the regional variation, the odd ratios of TNF-α-308 A in European and Asian populations were 2.08195%CI（1.59, 2.71）, P〈0.001] and 1.44195%CI（1.04, 2.01）, P=0.03], respectively. Conclusion： TNF-α-308 A/G polymorphism is associated with SLE susceptibility in European and Asian populations.