神经营养因子在多发性硬化神经再生修复中的作用研究进展

Research Progress on the Effects of Neurotrophic Factor in Nerve Regeneration of Multiple Sclerosis

神经营养因子(NTFs)是指一类能促进神经细胞存活、生长、分化的蛋白质,在胚胎时期即可调控人体的生长发育。在中枢神经系统中,NTFs不仅可减轻神经变性,还具有刺激轴突生长,促进再生的功能。多发性硬化(MS)是一种以髓鞘脱失和轴突损伤等为病理学特征的自身免疫介导的神经退行性病变。NTFs对MS疾病有神经再生和修复作用,为NTFs应用到MS患者的治疗提供了依据。

Neurotrephic factors（NTFs） are a kind of proteins that can promote the survival, growth and differentiation of nerve cells. NTFs can regulate the growth and development of the human body during the embryonic period. In the central nervous system （CNS）, it not only can reduce the nerve degeneration, but also has the function of stimulating axon growth and promoting the axonal regeneration. Multiple scleresis （MS） is a CNS autoimmune mediated neurodegenerative disease, pathologically characterized by demyelination and axonal injury NTFs have the function of nerve regeneration and repair in MS disease, which previds the basis for the treatment of MS patients with NTFs.