色素上皮衍生因子与糖尿病肾病的研究进展

Research Progress of Pigment Epithelium-Derived factor and Diabetic Nephropathy

糖尿病肾脏病变是糖尿病病程慢性进展(病程长,多超过10年)后并发的糖尿病特异性的微血管并发症之一。终末期肾脏疾病是导致糖尿病患者死亡的一个重要原因,但目前糖尿病肾病的发病机制尚不十分明确。近年来,色素上皮衍生因子(PEDF)在糖尿病肾病患者血清、尿液以及肾组织中的表达水平及其作用的研究逐渐增多,PEDF抗氧化应激等作用与糖尿病肾病的相关研究也逐渐得到学者们的关注。PEDF是糖尿病肾脏的保护性因素。

Diabetic nephropathy is one of the specific microvascular complications of chronic progressive course of diabetes（ long course for more than 10 years）. End-stage renal failure is an important cause of death in diabetic patients, However,the pathogenesis of diabetic nephropathy is not very clear,in recent years, the researches of expression level and function of pigment epithelium-derived faetor（PEDF） in the serum,urine and kidney tissues of the diabetic nephropathy are gradually increased year by year, as well as the research of its antioxidant stress in diabetic nephropathy,drawing more attention of many scholars. PEDF is a protective factor in diabetic kidney.