摘要
目的探讨瑞舒伐他汀片对急性脑梗死患者血脂、踝肱指数和颈动脉粥样硬化斑块的影响。方法选择2014年1月至2015年1月宜昌市第一人民医院神经内科收治的120例急性脑梗死患者为研究对象,按照随机数字法分为观察组和对照组,各60例。对照组采用常规的缺血性脑卒中治疗,血栓通冻干粉500 mg,加入5%葡萄糖注射液250 m L中静脉滴注,每日1次;观察组在常规治疗的基础上加用瑞舒伐他汀片治疗,每日10 mg。分别观察两组患者治疗前、治疗后6个月血脂、踝肱指数、颈动脉粥样硬化斑块变化情况。结果治疗后,观察组患者总胆固醇、三酰甘油、低密度脂蛋白胆固醇均低于对照组[(2.7±0.3)mmol/L比(5.0±1.1)mmol/L,(1.7±0.6)mmol/L比(2.9±0.7)mmol/L,(1.9±0.4)mmol/L比(3.6±0.6)mmol/L],差异有统计学意义(P<0.05)。治疗后,观察组患者踝肱指数高于对照组(0.75±0.24比0.59±0.21),差异有统计学意义(P<0.05)。治疗后,观察组颈总动脉的内中膜厚度低于对照组[(1.5±0.7)mm比(2.6±0.7)mm],低回声斑块、混合回声斑块比例低于对照组[26.7%(16/60)比53.3%(32/60),51.7%(31/60)比75.0%(45/60)],差异有统计学意义(P<0.05)。结论瑞舒伐他汀片可以降低急性脑梗死患者血脂水平,升高踝肱指数,并抑制颈动脉粥样硬化斑块的形成,疗效显著,值得在临床推广应用。
Objective To investigate the-effect'of rosuvasta-tin on serum iipids, ankle brachial index and carotid atherosclerotic plaque in patients with acute cerebral infarction. Methods Total of 120 cases of acute cerebral infarction treated in the First People's Hospital of Yichang from Jan. 2014 to Jan. 2015 were included in the study, according to the random number method they were divided into an observation group (60 cases) ,a control group(60 cases). The control group was treated with routine ischemic stroke treatment ( Xueshuantong lyophilized powder 500 mg, added into 250 mL of 5 % glucose injection for intravenous infusion, once per day) ;the observation group was also given rosuvastatin tablets for treatment (10 mg/d orally) on the basis of the routine treatment. The changes of blood lipid, ankle brachial index and carotid atheroscle- rotic plaque were observed of the two groups before and after 6 months of treatment were observed. Results After treatment, total cholesterol, triglycerldes, low-density lipoprotein cholesterol of the observation group were lower than those of the control group [ (2.7 ± 0. 3 ) mmol/L vs ( 5.0± 1.1 ) mmol/L, ( 1.7 ±0. 6 ) mmol/L vs (2.9 ±0.7) mmol/L, ( 1.9 ±0.4) mmol/L vs (3.6 ±0.6) mmol/L] ,the differences were statistically significant(P 〈 0. 05 ). After treatment, ankle-brachial index of the observation group was significantly higher than that of the control group (0.75 ±0.24 vs 0.59± 0.21 ) ,the difference was statistically significant ( P 〈 0. 05 ). After treatment, the common carotid artery intima thickness of the observation group was lower than that of the control group [ ( 1.5±0. 7 ) mm vs ( 2. 6± 0. 7 ) mm ], hypoechoic plaques, plaques hybrid echo ratio were lower than those of the control group [26. 7% (16/60) vs 53.3% (32/60), 51.7% (31/60) vs 75.0% (45/60) ], the differences were statistically significant (P 〈0. 05 ). Conclusion Rosuvastatin can reduce blood lipid level and increase the ankle brachial index in patients with acute cerebral infarctian,and inhibit the formation of carotid atherosclerotic plaque, with signfieant effectthus is worthy of promotion in clinical.
出处
《医学综述》
2016年第24期4920-4922,共3页
Medical Recapitulate
关键词
急性脑梗死
瑞舒伐他汀片
踝肱指数
颈动脉粥样硬化斑块
Acute cerebral infarction
Rosuvastatin tablets
Ankle brachial index
Carotid atherosclerotic plaque