厄贝沙坦联合氨氯地平治疗老年高血压伴2型糖尿病的临床疗效观察

Clinical Curative Effcet Observation of Irbesartan Combined Amlodipine in the Treatment of Senile Hypertension Patients with Type 2 Diabetes Mellitus

目的:探讨厄贝沙坦联合氨氯地平治疗老年高血压伴2型糖尿病的临床疗效。方法:选取112例老年高血压伴2型糖尿病患者,按照随机数字表法分为研究组和对照组,每组56例。对照组使用厄贝沙坦治疗,研究组使用厄贝沙坦联合氨氯地平治疗,比较两组患者治疗总有效率、治疗前后血压水平、糖代谢指标及不良反应发生情况的差异。结果:研究组治疗总有效率为91.1%,对照组为75%,研究组治疗总有效率高于对照组(P<0.05);研究组治疗后SBP、DBP分别为(132.71±10.21)mmHg、(80.13±8.76)mmHg,均低于对照组(P<0.05);治疗后,研究组空腹血糖和空腹胰岛素均低于对照组(P<0.05);两组不良反应发生率比较无统计学差异(P>0.05)。结论:厄贝沙坦联合氨氯地平治疗老年高血压伴2型糖尿病疗效好,不良反应少,值得临床推广使用。

Objective： To evaluate the clinical efficacy of irbesartan combined amlodipine in the treatment of senile hypertension patients with type 2 diabetes mellitus. Methods： 112 cases of senile hypertension patients with type 2 diabetes mellitus were selected and randomly divided into study group and control group, with 56 cases in each group.The control group was given irbesartan treatment,and the study group received irbesartan combined amlodipine treatment.The differences of total effective rate, blood pressure level, glucose metabolism index and adverse reactions were compared between the two groups.Results： The total effective rate of study group （91.1%） was higher than that of control group （75%）（P〈0.05）;The SBP and DBP ofstudy group after treatment were （ 132.71±10.21） mmHg and （80.13±8.76） mmHg respectively, which were lower than those of control group （P〈0.05）;After treatment,the fasting blood glucose and fasting insulin of study group were lower than those of control group （P〈0.05）.The adverse reactions of two groups had no significant difference （P〉0.05）.Conclusion： Irbesartan combined amlodipine in the treatment of senile hypertension patients with type 2 diabetes mellitus has good curative effect, with less adverse reactions, which is worth of clinical promotion and application.