JAK/STAT信号通路在刀豆蛋白A诱导的自身免疫性肝炎中的作用

Role of JAK/STAT Signal Pathway in Con A-induced Autoimmune Hepatitis

自身免疫性肝炎(autoimmune hepatitis,AIH)是一种由肝脏组织耐受性缺失导致的慢性炎症性疾病.刀豆蛋白A(concanavalin A,Con A)是一种提取自刀豆的植物凝集素.由Con A诱导的肝炎模型常用于研究AIH的动物模型.JAK激酶(janus-activated kinases,JAK)/信号传导与转录激活子(signal transducer and activator of transcription,STAT)信号通路是在该模型中研究比较多的细胞内信号转导通路.该模型中的关键细胞因子IFN-γ、IL-4、IL-12、IL-6及IL-22均可以通过JAK/STAT信号通路发挥作用.本文综述了IFN-γ/STAT1信号通路、IL-4/STAT6信号通路、IL-12/STAT4信号通路参与Con A诱导肝损伤产生的机制,同时综述了IL-6/STAT3信号通路、IL-22/STAT3信号通路对肝损伤的保护作用及可能的机制.

Autoimmune hepatitis（AIH） is a chronic inflammatory disease in which a loss of tolerance of hepatic tissue is presumed. The concanavalin A（Con A）-induced autoimmune hepatitis model in mice is a well established and widely used model for investigating the pathogenesis mechanisms and pathological changes of T-cell dependent liver injury. Janus-activated kinases/signal transducer and activator of transcription（JAK/STAT）signal pathway paly a critical role for intracellular signal transduction in this model. The relevant literatures concerning the mechanism of the IFN-γ/STAT1 signal pathway, IL-4/STAT6 signal pathway and IL-12/STAT4 signal pathway which involved in Con A-induced hepatitis and the role of the IL-6/STAT3 signal pathway and IL-22/STAT3 signal pathway in protecting against Con A-induced hepatitis were reviewed in this article.