心室细胞生成的生物起搏器的仿真研究

A Simulation Study of The Bio-pacemaker Induced From Ventricular Myocytes

植入电子起搏器可以治疗因窦房结功能失常引起的猝死等心脏疾病.但是,电子起搏器存在很多弊端,比如电池寿命有限、容易感染等.因此,生物起搏器被期待能够取代电子起搏器.为了探讨在心室内诱导心室细胞生成生物起搏器的可行性,我们首先抑制内向整流钾电流(I_(K1)),使心室肌细胞产生起搏行为,然后基于理想心室组织和真实人体心室切片数据,构建2D生物起搏器模型.基于该模型,我们研究细胞间的电偶联和起搏电流I_f对起搏器功能的影响.发现起搏电流I_f对起搏器功能有增强作用,但细胞间的弱电偶联对起搏器的起搏有更为关键的影响.

Heart diseases, e.g. sudden death, caused by the dysfunction of sino-atrial node could be treated by implanting electronic pacemakers, which, yet, have many disadvantages, such as the limited life of battery and infections. As a result, bio-pacemakers are expected to replace the electronic devices. In the paper, firstly, the inward-rectifier K~＋ current（I_（K1）） of the ventricular myocytes is inhibited to make the sing cell show automatic pacemaker activity. And then, based on the data of a human ventricular slice, we create a 2D tissue model of bio-pacemaker to investigate the feasibility of inducing bio-pacemaker in the right ventricle. Based on the model,the effects of electrical coupling and the funny current I_f on the pacemaker are discussed. We find that the pacing capability could be increased by both the weak coupling and strong I_f. However, the weak electrical coupling plays a more important role in the bio-pacemaker.