卡培他滨联合奥沙利铂动脉介入栓塞治疗宫颈癌的疗效及其对血管生长相关因子水平影响

Therapeutic efficacy of arterial interventional embolization using capecitabine combined with oxaliplatin and its effect on levels of vascular growth-related factors in patients with cervical cancer

目的观察卡培他滨联合奥沙利铂动脉介入栓塞治疗宫颈癌的疗效及其对血管生长因子水平的影响。方法将86例宫颈癌患者随机分为两组,每组43例;对照组给予卡培他滨+奥沙利铂静脉滴注,栓塞组应用卡培他滨+奥沙利铂动脉介入栓塞治疗,两组均治疗6个疗程。比较两组患者的近、远期临床疗效、不良反应发生率,以及治疗前后血管内皮细胞生长因子(VEGF)、成纤维细胞生长因子2(FGF-2)、碱性成纤维细胞(BFGF)和血小板衍生生长因子(PDGF)水平的变化。结果栓塞组治疗有效率为69.77%(30/43),明显高于对照组的46.51%(20/43)(P<0.05);栓塞组患者局部复发与转移率明显低于对照组(P<0.05);两组患者疾病控制率、不良反应发生率、平均生存时间、1年和2年生存率的比较,差异均无统计学意义(P>0.05)。治疗后,两组患者VEGF、PDGF、FGF-2和BFGF水平均明显下降(P<0.05),但栓塞组以上因子水平均低于对照组(P<0.05)。结论卡培他滨联合奥沙利铂动脉介入栓塞治疗可显著提高宫颈癌的近期疗效,并能抑制血管相关生长因子水平,降低肿瘤复发与转移。

Objective To observe the therapeutic efficacy of arterial interventional embolization using capeeitabine combined with oxaliplatin and its effect on levels of vascular growth-related factors in patients with cervical cancer. Methods Eighty-six patients with cervical cancer were randomly divided into two groups, with 43 cases in each group. The control group was intravenously administered with capecitabine and oxaliplatin, and the embolization group received arterial interventional embolization using capecitabine combined with oxaliplatin for six courses. Short-term and long-term clinical efficacy, incidence rate of adverse reactions, levels of vascular endothelial cell growth factor （ VEGF）, fibroblast growth factor-2 （ FGF-2 ）, basic fibroblast growth factor （ BFGF）, and platelet-derived growth factor （PDGF） before and after treatment were compared between the two groups. Results The therapeutic effective rate of the embolization group was 69.77% （30/43）, significantly higher than that of the control group [46.51% （20/43）, P 〈 0.05 ） ]. Both the local recurrence and metastasis rates of the embolization group were significantly lower than those of the control group （P 〈 0.05 ）. There were no statistical differences in disease control rate, incidence rate of adverse reactions, average survival time, or 1- and 2-year survival rates between the two groups （ P 〉 0.05 ）. After treatment,levels of VEGF, PDGF, FGF-2 and BFGF in both groups deereased significantly （ P 〈 0.05 ）, hut the levels of these factors were significantly lower in the embolization group than in the control group （ P 〈 0. 05 ）. Conclusion Arterial interventional embolization using capecitabine and oxaliplatin can significantly improve short-term efficacy, inhibit the levels of vascular growth-related factors, and reduce the recurrence and metastasis in patients with eervical eaneer.