Hsa-miR-149基因多态性与消化道肿瘤易感性的研究

The association between Has-miRNA-149 polymorphism and susceptibility of digestive tract cancer

目的：探讨Hsa‐miR‐149基因多态性与消化道肿瘤易感性之间的关系。方法检索Pubmed、EMBASE、ISIWebofScience、中国知网（CNKI）、万方等国内外数据库，收集关于Hsa‐miR‐149基因多态性与消化道肿瘤的病例对照研究文献。根据纳入排除标准选择符合的文献，提取数据以合并OR值和相应的95％置信区间（95％CI）来预测Has‐miRNA‐149基因多态性和消化道肿瘤的关系，根据异质性检验结果选择随机效应模型或固定效应模型，并进行敏感性分析和发表偏移的评估，应用Sta‐ta12．0分析软件进行统计分析。结果最终纳入13篇研究包括病例组4424例，对照组5290例。Hsa‐miR‐149基因多态性与消化道肿瘤易感性具有相关性（显性模型CT＋CCvs．TT：OR＝0．915，95％CI：0．840～0．996，P＝0．040；杂合子模型CTvs．TT：OR＝0．880，95％CI：0．803～0．965，P＝0．007）。分层分析发现，CT和CC基因型携带者患结直肠癌的风险明显降低（OR＝0．834，95％CI：0．715～0．972，P＝0．021）；亚洲人群里，Hsa‐miR‐149基因多态性与消化道肿瘤风险相关（显性遗传模型CT＋CCvs．TT：OR＝0．894，95％CI：0．818－0．977，P＝0．013），但与高加索人群的消化道肿瘤易感性的相关性不明显。结论Hsa‐miR‐149基因多态性与消化道肿瘤易感性密切相关，尤其在亚洲人群中，携带突变基因型CT／CC的个体与携带TT野生基因型相比患消化道肿瘤的风险降低。

Objective To investigate the association between Has‐miRNA‐149 polymorphism and susceptibility of digestive tract cancer .Methods A systematic search of Pubmed ,EMBASE and Web of Science ,CNKI ,Wanfang was conducted for relevant studies .The odds ratios（OR） and 95% confidence intervals（95% CI） calculated by Stata12 .0 software were used to assess the asso‐ciation between Has‐miRNA‐149 polymorphism and risk of digestive tract cancer .The Q test ,I2 value and funnel plot were conduc‐ted to examine heterogeneity and publication bias ,respectively .Results A total of thirteen eligible studies containing 4 424 cases and 5 290 controls were included in this Meta analysis .There were significant relationships between Hsa‐miRNA‐149 polymorphism and susceptibility of digestive tract cancer （Domina model CT＋CC vs .TT ,OR=0 .915 ,95% CI：0 .840-0 .996 ,P=0 .040 ;Hetero‐zygous model CT vs .TT ,OR=0 .880 ,95% CI：0 .803 -0 .965 ,P=0 .007） .In the stratified analysis ,it was found that the risk of colorectal cancer decreased in patients carrying CC/CT genotypes（OR=0 .834 ,95% CI：0 .715-0 .972 ,P=0 .021） ,especially in A‐sians （CT＋CC vs .TT ,OR=0 .894 ,95% CI：0 .818-0 .977 ,P=0 .013） ,while that was not found in the Caucasoids .Conclusion Has‐miRNA‐149 polymorphism is associated with the susceptibility of digestive tract cancer .The CC/CT genotypes may decrease the risk of digestive tract cancer ,especially in Asians .