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饥饿素与糖尿病相关性的研究进展

Research progress of ghrelin and diabetes mellitus
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摘要 近年来,研究发现饥饿素与糖脂代谢、炎症及其并发症密切相关,对糖尿病的发生发展产生影响。为此,本文就饥饿素对糖尿病及以上各方面影响作一综述。 Recent studies have found that ghrelin is closely related to glucolipid metabolism,inflammation and complications of diabetes, and may exert effect on the development of diabetes. In this article, we summarize the relationship between ghrelin and diabetes and above all parties.
出处 《重庆医科大学学报》 CAS CSCD 北大核心 2016年第11期1168-1171,共4页 Journal of Chongqing Medical University
基金 国家自然科学基金面上资助项目(编号:81270911) 国家临床重点专科建设资助项目(编号:财社[2011]170号)
关键词 饥饿素 糖尿病 ghrelin diabetes mellitus
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  • 1Scrocchi LA, Brown TJ, Maclusky N, et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon- like peptide 1 receptor gene [ J ]. Nat Med, 1996,2 ( 11 ) : 1254- 1258.
  • 2Li Y, Hansotia T, Yusta B, et al. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis [ J ]. J Biol Chem, 2003, 278( 1 ) :471-478.
  • 3Hansotia T, Maida A, Flock G, et al. Extrapancreatic incretin re- ceptors modulate glucose homeostasis, body weight, and energy expenditure [ J ]. J Clin Invest ,2007,117 ( 1 ) : 143-152.
  • 4Yusta B, Baggio LL,Estall JL, et al. GLP-1 receptor activation improves beta cell function and survival following induction of en- doplasmic reticulum stress [ J ]. Cell Metab, 2006,4 ( 5 ) : 391 - 406.
  • 5Elbrnd B,Jakobsen G,Larsen S, et al. Pharmacokinetics, phar- macodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects [ J ]. Diabetes Care, 2002,25 ( 8 ) : 1398- 1404.
  • 6Wang M, Kipnes M, Matheson S, et al. Safety and pharmacody- namics of CJC-1134-PC, a novel GLP-1 receptor agonist,in pa- tients with type 2 diabetes mellitus : a randomized, Placebo-Con-trolled ; Double-Blind, Dose-Escalation study [ J ]. Diabetes ,2007, 56(Suppl 1) :A133.
  • 7Baggio LL,Huang Q,Cao X, et al. An albumin-exendin- conju- gate engages central and peripheral circuits regulating murine en- ergy and glucose homeostasis [ J ]. Gastroenterology, 2008,134 (4) :1137-1147.
  • 8Drucker DJ. Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes : preclinical biology and mechanisms of action [ J]. Diabetes Care ,2007,30 ( 6 ) : 1335-1343.
  • 9Hansotia T,Baggio LL, Delmeire D, et al. Double incretin recep- tor knockout (DIRKO) mice reveal an essential role for the en- teroinsular axis in transducing the glucoregulatory actions of DPP- IV inhihitors [ J ]. Diabetes,2004,53 ( 5 ) : 1326-1335.
  • 10Ussher JR, Drueker DJ. Cardiovascular biology of the incretin sys- tem[ J]. Endoer Rev ,2012,33 (2) : 187-215.

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