5岁以下儿童接种b型流感嗜血杆菌疫苗流行病学效果的Meta分析

A meta-analysis of vaccine efficacy of haemophilus influenza type b vaccine among children under five years of age

目的对5岁以下儿童接种b型流感嗜血杆菌疫苗（Hib）的流行病学保护效果进行Meta分析。方法检索美国国家医学图书馆数据库（NCBI）、Cochrane协作网图书馆数据库、中国生物医学文献数据库、中国期刊全文数据库和万方全文数据库,采用Rev Man 5.3软件对纳入的有关5岁以下儿童接种Hib的流行病学保护效果的文献进行Meta分析。结果共纳入9篇文献,其中7篇为随机对照试验,2篇为半随机对照试验。接种1、2和3剂次Hib后产生的疫苗保护率分别为65%（95%CI：23%~84%）、79%（95%CI：54%~90%）和85%（95%CI：77%~90%）。结论 Hib具有良好的保护效果,2剂次和3剂次Hib基础免疫程序在5岁以下儿童中的保护效果相似。

Objective To evaluate vaccine efficacy（VE） of Haemophilus influenza type b vaccine（Hib） among children under five years of age.Methods Searching＂National Center for Biotechnology Information,NCBI＂,＂Cochrane Library,CL＂,＂China Biology Medicine disc,CBMd＂,＂China National Knowledge Infrastructure,CNKI＂,＂ Wanfang Database,the studies of VE for Hib among children under five years of age were included,and meta-analysis were made by Rev Man5.3 software.Results A total of 9 studies were included,seven were randomised clinical trial（RCT） design and two were semi RCT design.The VEs of one dose,two doses and three doses of Hib were 65%（95% CI： 23%-84%）,79%（95%CI： 54%-90%）,and 85%（95% CI： 77%-90%）,respectively.Conclusion We found that Hib is highly effective and that the two dose regime is as good as the three dose regime.