莫沙比利联合奥美拉唑治疗胃食管反流病的效果研究

Effect study of Mosapride combined with Omeprazole treating gastroesophageal reflux disease

目的 探讨莫沙比利联合奥美拉唑治疗胃食管反流病的临床效果。方法 选取2013年7月~2014年7月我院收治的94例胃食管反流病患者,依据患者入院就诊时间随机分为对照组、观察组,每组47例。给予对照组患者奥美拉唑进行治疗,观察组在对照组治疗基础上加用莫沙比利,比较两组患者的治疗效果和不良反应发生率。结果 观察组患者的总有效率为91.49%,显著高于对照组的70.21%,差异有统计学意义（P〈0.05）。观察组的不良反应发生率为4.26%,显著低于对照组17.02%,差异有统计学意义（P〈0.05）。结论 莫沙比利联合奥美拉唑治疗胃食管反流病的效果显著,可显著降低降低不良反应发生率,值得临床进一步推广应用。

Objective To investigate the clinical effect of Mosapride combined with Omeprazole treating gastroe- sophageal reflux disease.Methods 94 patients with gastroesophageal reflux disease treated in our hospital from July 2013 and July 2014 were selected and randomly divided into control group and observation group according to the time of hospitalization,and each group had 47 cases.Control group was treated by Omeprazole,while observation group was added Mosapride on the basis Of treatment of control group.Treatment effect and incidence rate of adverse reaction in patients were compared between two groups.Results The total effective rate in the observation group （91.49%） was ob- viously higher than that of.control group （70.21%）,and there was a statistical difference （P〈0.05）.The incidence rate of adverse reaction in observation group （4.26%） was obviously higher than that of control group （17.02%） and there was a statistical difference （P〈0.O5）.Conclusion The effect of Mosapride combined with Omeprazole treating gastroe- sophageal reflux disease is significant,and can obviously reduce the incidence rate of adverse reaction,and it is worthy of further promotion and application in clinic.