头颅局部亚低温联合醒脑静治疗急性脑出血疗效观察

Effects observation of Xingnaojing combined with hypothermia in treatment of acute cerebral hemorrhage

目的:探讨头颅局部亚低温联合醒脑静治疗急性脑出血的效果。方法:选择122例急性脑出血患者,根据随机数字表法分为治疗组与对照组,每组61例。对照组给予头颅局部亚低温治疗,治疗组在对照组治疗的基础上加用醒脑静注射液,治疗观察周期为14 d。结果:治疗后治疗组与对照组的总有效率分别为96.7%和86.9%,2组比较差异有统计学意义(P<0.05)。治疗组与对照组治疗后血肿体积分别为(10.45±2.45)cm3和(14.20±3.53)cm3,都明显低于治疗前的(16.44±3.14)cm3和(16.33±2.98)cm3(P<0.05),治疗后治疗组的血肿体积也明显少于对照组(P<0.05)。2组治疗后血清一氧化氮(NO)含量明显增加,而内皮素(ET)含量明显降低,与治疗前比较,差异有统计学意义(P<0.05);同时治疗后治疗组血清ET与NO含量与对照组比较差异均有统计学意义(P<0.05)。结论:头颅局部亚低温联合醒脑静治疗急性脑出血能减少脑水肿体积,有利于维护内皮细胞分泌的ET和NO处于动态平衡状态,从而提高总体治疗效果。

Objective：To investigate the effect of Xingnaojing combined with hypothermia in treatment of acute cerebral hemor- rhage. Methods： 122 acute cerebral hemorrhage patients were selected and equally divided, according to the random number table,into a treatment group and a control group. The control group was given local mild hypothermia treatment on the head, and the treatment group, on the basis of the control group, was added with Xingnaojing injection. The treatment observation lasted 14 days. Results：After the treatment, the total efficacy in the treatment group and the control group was 96.7% and 86.9% respectively, with the treatment group g significantly higher （P 〈 0.05）. The hematoma volumes in the treatment group and control group were 10.45 ± 2.45 cm^3 and 14. 20 ± 3.53cm^3 respectively, significantly lower than 16.44 ± 3.14cm^3 and 16.33 ±2.98cm^3 before treatment （ P 〈 0.05 ） , and the volume in the treatment group was also lower than that of the control group. The difference was statistically significant （ P 〈 0.05 ）. Serum nitric oxide （ NO ） levels of the 2 groups after the treatment significantly increased, and serum endothelin （ET） levels significantly reduced, which were significantly different from before the treatment （ P 〈 0.05 ）. Compared with the control group, the differences of serum ET and NO in the treatment group after treatment were statistically significant （ P 〈 0.05 ）. Conclusion- Xingnaojing combined with hypotherrnia in treatment of acute cerebral hemorrhage can reduce the volume of brain edema. It is conducive to the maintenance of ET and NO dynamic equilibrium state, thereby improving the overall treatment effect.