大动脉炎冠状动脉受累的危险因素分析

Analysis of risk factors of coronary artery involvement in Takayasu arteritis

目的：冠状动脉受累是大动脉炎患者死亡的主要原因之一，本研究旨在寻找大动脉炎患者冠状动脉受累的危险因素。方法回顾性分析64例大动脉炎累及冠状动脉的患者和73例大动脉炎未累及冠状动脉的患者的临床特点，采用Logistic回归模型评价各危险因素与冠状动脉病变的关系。结果大动脉炎累及冠状动脉的患者发病更晚，年龄更大，高脂血症、糖尿病的患病率更高， Logistic回归分析提示晚发大动脉炎是大动脉炎患者发生冠状动脉病变的独立危险因素（ OR＝3．724，95％CI：1．289～10．763，P＝0．015）。结论晚发大动脉炎更易发生冠状动脉受累。

Objective Coronary artery involvement is one of major causes of death in patients with Takayasu arteritis（TA） ,we aim to search for potential risk factors of coronary artery involvement in patients with TA. Methods The clinical characteristics of 64 TA patients with involving coronary arteries and 73 TA patients without involving coronary arteries were retrospectively analyzed .The logistic regression analysis model was used to assess the relationship between potential risk factors and coronary artery disease . Results TA patients with coronary artery involvement were older and with later onset ,higher prevalence of hyperlipidemia and diabetes mellitus .The multivariate logistic regression analysis showed that later onset of TA（OR =3.724,95%CI：1.289-10.763,P =0.015） was independently associated with coronary artery involvement in patients with TA . Conclusions Late-onset of TA is more likely to involve coronary arteries than early-onset of TA.