原发性高血压患者S状室间隔性别差异分析

Gender difference in essential hypertensive patients with sigmoid-shaped ventricular septum

目的：利用超声心动图的二维及彩色多普勒技术了解原发性高血压患者男女不同性别之间室间隔形态的差异，探讨S状室间隔的发生率与性别是否存在相互关联，并分析其对左心室流出道内径（ LVOTD）及左心室流出道收缩期血流速度（ LVOTS）的影响。方法对2510例原发性高血压患者进行超声心动图像分析，测量室间隔厚度、形态、LVOTD及LVOTS，其中241例确诊为S状室间隔，并按性别分组。结果在241例原发性高血压合并S状室间隔患者中，女性148例，占61．4％；男性93例，占38．6％，差异有统计学意义（χ2＝12．56，P＝0．000）；男女LVOTD差异有统计学意义[（26．3±3．6） mm 比（21．8±3．0） mm，t ＝0．092，P ＝0．008]；男女 LVOTS 差异无统计学意义[（136．0±37．3）cm／s比（140．5±40．1）cm／s，t＝0．334，P＝0．221]。结论 S状室间隔的发生率存在明显的性别差异，应进一步了解其原因，指导临床合理预防及治疗。

Objective To study the relationship between the occurrence of sigmoid-shaped ventricular septum and the gender of the patients with essential hypertension , and its influence on left ventricular outflow tract diameter （ LVOTD） and left ventricular outflow tract blood flow velocity in systole （ LVOTS） using two-dimensional echocardiography and color doppler technology . Methods We enrolled 2 510 patients with essential hypertension and measured the thickness and morphology of ventricular septum , LVOTD and LVOTS for all patients.The 241 patients were diagnosed as sigmoid-shaped ventricular septum , and categorized according to gender . Results In 241 patients with sigmoid-shaped ventricular septum ,148 were females（61.4%）and 93 were males（38.6%）,difference was statistically significant （χ2 =12.56,P=0.000）;LVOTD between genders was statistically significant [（26.3 ±3.6） mm vs.（21.8 ±3.0） mm,t=0.092,P =0.008],LVOTS between genders had no significant difference [（136.0 ±37.3） cm/s vs. （140.5 ±40.1）cm/s,t=0.334,P=0.221]. Conclusions The incidence of sigmoid-shaped ventricular septum has significant difference between genders .We should further explore the cause of the difference to guide the clinical rational prevention and treatment .