E-cadherin、Vimentin和Snail在初发、复发鼻咽癌组织中表达的差异

Expression of E-cadherin,Vimentin and Snail in primary and recurrent nasopharyngeal carcinoma

目的通过检测上皮间质转化(EMT)相关标志物上皮钙黏连素(E-cadherin)、波形蛋白(Vimentin)和Snail在初发和复发鼻咽癌(NPC)组织中的表达差异,探讨差异表达的蛋白与NPC转移、复发的关系。方法选择32例NPC患者为研究对象,通过免疫组化方法检测E-cadherin、Vimentin和Snail蛋白在初发和复发NPC组织中的表达差异。结果复发NPC组织中E-cadherin的表达明显低于初发NPC,差异具有统计学意义(P<0.05),复发NPC组织中Vimentin和Snail的表达明显高于初发NPC,差异具有统计学意义(P<0.05)。结论复发NPC组织中存在EMT现象,E-cadherin、Vimentin和Snail蛋白与NPC转移、复发密切相关。

Objective To investigate the differential expression of epithelial-mesenchymal transition（ EMT）-associated markers including E-cadherin,Vimentin and Snail in primary and recurrent nasopharyngeal carcinoma（ NPC）,and to explore its relationships with NPC metastasis and recurrence. Methods Clinical data of 32 cases of NPC in 175 th Hospital of PLA were collected. The expression of E-cadherin,Vimentin and Snail was determined in primary and recurrent NPC by immunohistochemistry. Results E-cadherin expression was significantly lower in recurrent NPC than in primary NPC（ P 〈0. 05）. Vimentin and Snail expression was significantly higher in recurrent NPC than in primary NPC（ P 〈0. 05）. Conclusion EMT exists in recurrent NPC. Expression of E-cadherin,Vimentin and Snail may be closely related to the recurrence and metastasis of NPC.