血清salusin-β水平与高血压患者合并冠心病及其严重程度的相关性

Correlation of serum salusin-β levels with the presence and severity of coronary artery disease in hypertensive patients

目的探讨血清salusin-β水平与高血压患者合并冠心病及其严重程度的关系。方法共纳入190名高血压患者及58名健康对照者,采用酶联免疫吸附法(ELISA)测量研究对象的血清salusin-β水平,采用SYNTAX评分评价冠心病的严重程度,评价血清salusin-β水平与冠心病的发病及严重程度的关系。结果在190例高血压患者中,合并冠心病者血清salusin-β水平较未合并冠心病者显著升高[4.49(3.58-5.99)nmol/L vs 4.00(3.24-5.18)nmol/L,P<0.01]。血清salusin-β水平与冠心病发病存在独立正相关(优势比1.345,95%CI 1.069-1.694;P=0.012)。合并冠心病患者的血清salusin-β水平与SYNTAX评分呈正相关(r=0.279,P=0.006)。结论血清salusin-β水平与高血压患者合并冠心病及其严重程度相关,salusin-β有望成为预测高血压患者冠心病发生发展的生物标记物。

Objective To explore the relationship between serum salusin-β levels and the presence and severity of coronary artery disease（ CAD） in patients with hypertension. Methods A total of 190 hypertension patients and 58 healthy controls were enrolled. Serum salusin-β levels were measured by SYNTAX score. The correlation between serum salusin-β levels and the presence and severity of CAD was evaluated. Results Serum salusin-β level was significantly higher in hypertensive patients with CAD than that in those without CAD [4. 49（ 3. 58- 5. 99） nmol / L vs 4. 00（ 3. 24- 5. 18） nmol / L,P 〈0. 01]. Serum salusin-β level was independently associated with the presence of CAD in hypertensive patients（ odds ratio 1. 345,95% CI 1. 069- 1. 694; P = 0. 012）. Serum salusin-β level was positively correlated with SYNTAX scores in CAD patients（ r = 0. 279,P = 0. 006）. Conclusion Serum salusin-β level is correlated with the presence and severity of coronary artery disease in hypertensive patients. Salusin-β might be a potential biomarker for predicting the development and progression of CAD in hypertensive patients