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儿童抗NMDA受体脑炎16例临床分析 被引量:2

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摘要 目的总结儿童抗N-甲基-D-天冬氨酸(N-methyl-D-asparatic acid,NMDA)受体脑炎的诊治情况,为提高其诊治水平提供依据。方法回顾性分析16例抗NMDA受体脑炎儿童的临床诊治情况。结果 16例患儿脑脊液抗NMDA受体抗体均为阳性,16例脑电图检测,7例表现为广泛高幅慢波,9例除慢波外,有局灶性痫样放电。16例患儿均应用一线药物丙种球蛋白、皮质醇激素治疗,2例因一线用药治疗效果差给予二线免疫治疗,均予以利妥昔单抗治疗,随访1-2年,1例有轻微后遗症,1例复发。余基本恢复正常,无1例出现肿瘤。结论儿童抗NMDA受体脑炎临床表现与成人相似,但少见肿瘤,脑脊液抗NMDA受体抗体阳性,是其诊断金标准;及时给予免疫治疗,多数患儿预后比较良好。
出处 《山西医科大学学报》 CAS 2016年第12期1115-1117,共3页 Journal of Shanxi Medical University
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