异丙托溴铵、布地奈德、博利康尼联合雾化吸入对慢性阻塞性肺疾病加重期的疗效观察

Results observation of AECOPD treated with aerosol inhalation, Budesonide, Terbutaline and Ipratropium Bromide

目的探讨异丙托溴铵、博利康尼及布地奈德联合雾化吸入对COPD急性发作期(AECOPD)患者的疗效。方法选择92例COPD急性期患者,随机分为观察组和对照组各46例,两组患者首先采用吸氧、抗感染、化痰止咳等综合治疗。对照组在综合治疗的基础上加用布地奈德及博利康尼雾化吸入,观察组在对照组用药的基础上加用异丙托溴铵气雾剂,连用1周。观察两组患者治疗前后肺功能情况(FEV1、FVC、FEV1%)、血气水平(PaO_2、PaCO_2)和临床疗效的变化。结果雾化吸入1周后两组患者的肺功能指标(FEV1、FVC、FEV1%)均较治疗前明显改善(P<0.05),观察组改善幅度高于对照组(P<0.05);两组患者的血气水平(PaO_2、PaCO_2)均较治疗前明显改善(P<0.05),观察组改善幅度高于对照组(P<0.05);两组患者的临床临床疗效相比观察组高于对照组(P<0.05)。结论异丙托溴铵、布地奈德、博利康尼联合雾化吸入对COPD急性加重期患者疗效显著,可明显改善患者的肺功能及临床症状。

Objective To observe the results of Aerosol inhalation, Terbutaline, Budesonide and Ipratropium Bromide Treatment on AECOPD patients. Methods 92 patients with AECOPD were randomly divided into observation group and control group, 46 cases in each group. Patients in the both two groups were given oxygen, anti-infection, phlegm cough etc first. The control group on the basis of the above treatment with budesonide, terhutaline and ipratropium Bromide. On the basis of the observation group in the control group used isopropyl bromide aerosol. They are continuous use one week. Observe two groups before and after treatment in patients with pulmonary function condition （FEV1 and FVC, FEV1%）, blood gas levels （PaO2, PaCO2 ） , and the change of clinical curative effect. Results Two groups of lung function index （ FEV1 , FVC, FEV1%） were obviously improved （P〈 0.05 ） After Atomization inhalation one week. Observation group is better than the control group （P〈 0.05 ）. Two groups with blood gas levels （PaO2, PaCO2 ） than before treatment significantly improved （P〈0.05）. Observation group is better than the control group（P〈0.05）. Two groups of patients with the clinical curative effect of observation group is higher than the control group （ P〈 0.05）. Conclusion Treated with isopropyl bromide, budesonide, terbutaline and aerosol inhalation of AECOPD patients the curative effect is remarkable. It can significantly improve the patients＇lung function and clinical symptoms.