产后抑郁大鼠模型的构建及参归仁合剂对其抑郁样行为的影响

Establishing a Model of Postpartum Depression on Rats and the Effects of Depression Behavioral for ShenGuiRen Mixture

目的:建立产后抑郁症(PPD)大鼠模型,观察参归仁合剂对其抑郁样行为的影响。方法:150只雌性大鼠随机分为空白组、PPD模型组、舍曲林组、雌二醇组、参归仁组(高、中、低剂量),每组设1、2、4周观察时点,分别对其进行行为学测试并观察其抑郁样行为。结果:与空白组比较,PPD模型组各时点大鼠体重增加缓慢,旷场实验水平运动得分、垂直运动得分降低,强迫游泳不动时间显著延长,糖水消耗量明显下降(P<0.001);与PPD模型组比较,参归仁高、中、低剂量组和阳性对照组各项指标均有明显改善(P<0.001或P<0.01)。结论:产后抑郁大鼠表现出抑郁样行为,参归仁合剂能够改善其行为学指标,具有抗抑郁作用。

Objective： It was establishpaed a model of postpartum depression on rats, and was observed the effects of depression be- havioral for shenguiren mixture. Methods： 150 female rats were divided into control group and model group（shenguiren high, medi um and low groups,sertraline group,estradiol group, depression model group）, and it has three points about 1,2,4weeks for each group. Then they were test behavioral and observed their depression behavior indictors. Results： The rats of PPD model group on which were weight increased slowly , were significantly prolonged of the central stay and in horizontal and vertical scores of OFT each point. Compared with control group, it has significant difference（P〈0. 001）;Compared with PPD model group, their indicors were obviously improved on shenguiren high, medium, low groups and positive control groups, they were significant difference（P〈0. 001）. Conclusion：Postpartum depression rats showed the depression behavioral, shenguiren mixture can improved the behavioral indica- tors, and it has antidepressant effect.