血清癌胚抗原、糖类抗原CA125、CA153联合检测在卵巢癌早期诊断中的应用

Application of Combined Detection of Serum CEA,CA125 and CA153 in Early Diagnosis of Ovarian Cancer

目的研究血清癌胚抗原(CEA)、糖类抗原CA125、CA153联合检测在卵巢癌早期诊断中的应用价值及临床意义。方法采用西门子ADVIA Centaur XP全自动化学发光免疫分析仪分别检测62例正常健康体检对照组,42例良性卵巢囊肿组,36例卵巢癌患者组血清中CEA、CA125和CA153的含量。结果卵巢癌患者组血中CEA、CA125和CA153的含量明显高于其他两组(P<0.05)。联合检测的阳性率、准确性均有明显提高。结论血清CEA、CA125和CA153在临床实验室检测中三者联合检测有利于提高卵巢癌早期诊断的阳性率,对早期卵巢癌的诊断有重要意义。

Objective To study the application values of combined detection of serum CEA,CA125 and CA153 in early diagnosis of ovarian cancer. Methods The CEA,CA125 and CA153 were detected by the SIEMENS ADVIA Centaur XP automatic chemiluminescence immunoassay analyzer for the three groups： the control group（ 62 healthy cases）,benign ovarian cyst group（ 42 cases） and ovarian cancergroup（ 36 cases）.Results The CEA,CA125 and CA153 in the ovarian cancer group were significantly higher than those in the other two groupswith statistical significance（ P〈0. 05）.The positive rate and accuracy of combined detection were significantly improved.Conclusion The combined detection of serum CEA,CA125 and CA153 in clinical laboratory tests is beneficial to improve the positive rate of early diagnosis of ovarian cancer,and it is of great significance for early diagnosis of ovarian cancer.