男性不育症患者精液支原体的检测及耐药性分析

Detection and Analysis of Drug Resistanceof Semen Mycoplasma in Male Infertility Patients

目的分析男性不育症患者精液支原体的检测和耐药性。方法选取2015年6月—2016年6月来我院治疗的男性不育症患者298例,通过培养法检测患者精液中的支原体情况,并进行药敏检测,观察其耐药性。结果在298例患者的标本中,有137例为支原体感染,感染率为45.97%。其中有117例为单纯解脲支原体感染,感染率为85.40%;有4例为单纯人支原体感染,感染率为2.92%;有16例为解脲支原体与人支原体混合感染,其感染率为11.68%。在抗生素药物中,解脲支原体感染对强力霉素、交沙霉素以及阿奇霉素的敏感性较高;人支原体感染对强力霉素、交沙霉素的敏感性最高;解脲支原体与人支原体混合感染对氧氟沙星、米诺环素、交沙霉素以及阿奇霉素较为敏感。结论临床应重视对男性不育症患者精液支原体的药敏检测,依照检测结果恰当用药,尽可能避免耐药菌株的大量出现。

Objective To investigate the detection and drug resistance of semen mycoplasmain male infertility patients.Methods 298 cases of male infertility in our hospital from June 2015 to June 2016 were selected.The drug sensitivity test was carried out to observe the drug resistance. Results In 298 cases,137 cases were mycoplasma infection and the infection rate was 45. 97%.117 cases were simple Ureaplasmaurealyticum infection and the infection rate was 85. 40%. 4 cases were Mycoplasma hominis infection and the infection rate was 2. 92%. 16 cases weremixed infectionwith Ureaplasmaurealyticum and Mycoplasma hominis and the infection rate was 11. 68%. In antibiotics,the sensitive rate of Ureaplasmaurealyticuminfection to Doxycycline,Josamycin and Azithromycin was higher.The sensitive rate of Mycoplasma hominis infection to Doxycycline and Josamycinwas highest.The Ureaplasmaurealyticum and Mycoplasma hominis mixed infection to Ofloxacin,Minocycline,Josamycin,Azithromycinwas more sensitive.Conclusion Attention should be paid to the drug sensitivity test of semen mycoplasma in male infertility patients.According to the results of the test,the right use of drugscan avoid the emergence of drug resistant strains.