子宫内膜癌患者雌激素受体、孕激素受体、Ki-67的表达及其临床意义研究

Clinical significance of estrogen receptor,progesterone receptor and the expressionof Ki-67 in endometrial cancer

目的:分析子宫内膜癌患者雌激素受体(ER)、孕激素受体(PR)、Ki-67的表达及其临床意义。方法:按照数字表法随机选取2013年1月至2015年6月60例医院收诊子宫内膜癌患者(观察组)、60例子宫内膜非典型增生患者(对照组)与60例正常增生体检者(正常组),三组均采用免疫组化表达法测得ER、PR以及Ki-67。结果:正常组ER及PR远高于观察组与对照组,对照组则显著高于观察组,差异有统计学意义(P<0.05);正常组Ki-67表达例数非常少,仅有3例,观察组显著高于对照组(P<0.05)。60例子宫内膜癌患者中,不同分化程度、病理分期和肌肉浸润的患者ER表达率均无显著差异(P>0.05)。不同分化程度中,低分化组的PR表达率显著低于中、高分化组,而Ki-67的表达率显著高于中、高分化组(P<0.05),中、高分化组之间比较无显著差异(P>0.05)。各病理分期的PR表达率无显著差异(P>0.05),Ⅰ期患者的Ki-67表达率显著低于Ⅱ、Ⅲ期患者(P<0.05),Ⅱ期、Ⅲ期组间比较,无显著差异(P>0.05)。无肌肉浸润与≥50%肌肉浸润者的PR及Ki-67表达率均无显著差异,此两组患者的PR及Ki-67表达率均显著低于<50%肌肉浸润组(P<0.05)。结论:ER、PR以及Ki-67表达与子宫内膜癌有一定的关系,其能够反映子宫内膜癌的病变程度以及预后情况,同时能够作为临床治疗子宫内膜癌的依据。

Objectives： To analyze the clinical significance of estrogen receptor（ ER）,progesterone receptor（ PR） and the expression of Ki- 67 in endometrial cancer. Methods： According to the digital table,60 endometrial cancer patients（ observation group）,60 cases of endometrial atypical hyperplasia patients（ control group） and 60 cases of normal proliferative physical examination persons（ normal group） in our hospital from January 2013 to June 2015 were randomly selected. Three groups were treated with immune group expression to measure Er,PR and Ki- 67 levels of three groups. Results： The ER and PR levels of normal group were much higher than these in the observation group and the control group. ER and PR levels of control group was significantly higher than these in observation group,with statistically significant difference（ P〈0. 05）; the number Ki- 67 expression in normal group was very small,only 3 cases.The number Ki- 67 expression in observation group was significantly higher（ P〈0. 05）. In 60 cases of endometrial carcinoma,there was no significant difference in the expression of ER in different degree of differentiation,pathologic stage and muscle infiltration（ P〉0. 05）; The expression of Ki- 67 was significantly higher than that in the well- differentiated group（ P〈0. 05）,and the expression of PR was significantly lower in the poorly differentiated group than in the moderately and well differentiated group No significant difference（ P〉0. 05）; The expression of Ki- 67 was significantly lower in patients with stage I disease than that in stage II and III（ P〈0. 05）,but there was no significant difference between stage Ⅱand stage Ⅲ（ P〉0. 05）; There was no significant difference in PR and Ki- 67 expression between muscle infiltration and muscle infiltration（ P〈0. 05）; The PR and Ki- 67 expression rates in both groups were significantly lower than those in 50% muscle infiltration group（ P〈0. 05）. Conclusion： ER,PR and Ki- 67 expression and endometrial cancer have a certain relationship,which can reflect the severity and prognosis of endometrial cancer,and it can be used as clinical treatment basis for endometrial cancer.