乳酸菌阴道胶囊联合戊酸雌二醇治疗老年性阴道炎的临床疗效及随访分析

Curative effect and follow-up analysis of lactic acid bacteria vagina capsule combined pentanoic acid estradiol for the treatment of senile vaginitis

目的:探究与分析乳酸菌阴道胶囊联合戊酸雌二醇治疗老年性阴道炎的临床疗效及随访复发率。方法:选取我院自2013年12月至2015年12月收治的90例老年阴道炎患者,采取随机数字表法分为对照组与观察组,每组各45例,对照组仅在阴道内放置乳酸菌阴道胶囊,观察组在其基础上加用戊酸雌二醇,对比两组患者临床疗效、激素变化及随访半年复发率。结果:对照组总有效率为73.33%,观察组总有效率为93.33%,观察组总有效率明显高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗前E2、P、FSH及LH水平相比无明显差异(P>0.05)。两组患者治疗后较治疗前相比E2、P、FSH及LH水平虽有改变,但均无明显差异(P>0.05)。两组治疗后E2、P、FSH及LH水平分别相比也无明显差异(P>0.05)。对照组随访半年复发率为26.67%,观察组随访半年复发率为13.33%,观察组随访半年复发率明显低于对照组(P<0.05)。结论:采用乳酸菌阴道胶囊联合戊酸雌二醇治疗老年性阴道炎的临床疗效显著,不会对体内激素水平造成影响,随访半年内的复发率较低,可发挥治疗及预防的双重作用。

Objectives： To explore and analyze the clinical curative effect and follow- up occurrence rate of lactic acid bacteria vagina capsule combined pentanoic acid estradiol for the treatment of senile vaginitis. Methods：90 patients with senile vaginitis in our hospital from December 2013 and December 2015 were selected and randomly divided into control group and observation group,with 45 cases in each group. Control group only received lactobacillus vagina capsule placed in the vagina,and based on the treatment of control group,observation group received pentanoic acid estradiol additionally. Clinical efficacy,hormone changes,recurrence rate in the six months＇ follow- up of the two groups was compared. Results： Total effective rate of control group was 73. 33% and total effective rate of observation group was 93. 33%,with statistically significant difference（ P〈0. 05）. E2,P,FSH and LH levels before treatment of two groups had no significant difference（ P〉0. 05）. After treatment,although E2,P,FSH and LH levels of two groups changed compared with these before treatment,there was no obvious difference（ P〉0. 05）. The differences in E2,P,FSH and LH levels between two groups after treatment had no significant difference（ P〉0. 05）. The recurrence rate of control group in the six months＇ follow- up was 26. 67%,and it was 13.33% in observation group,with statistically significant difference（ P〈0. 05）. Conclusion： Lactobacillus vagina capsule combined pentanoic acid estradiol has significant clinical curative effect for the treatment of senile vaginitis,and does not affect the hormone levels. With a low recurrence rate,it plays a dual role of both treatment and prevention.