不同方法治疗妊娠期外阴阴道念珠菌感染患者的临床疗效对比

Efficiency comparison of different methods in the treatment of patients with vaginal Candida infection in pregnancy

目的:探讨不同方法治疗妊娠期外阴阴道念珠菌感染患者的临床疗效。方法:选取2013年10月至2015年10月于我院接受治疗的妊娠期外阴阴道念珠菌感染患者110例,按照治疗方法的不同分为单用组和联用组,每组各55例。其中单用组每晚睡前用小苏打液冲洗阴道外阴后于阴道内放置克霉唑栓,联用组在此基础上加用硝酸咪康唑霜涂擦瘙痒处。两组患者均持续治疗1周。随访患者直至胎儿出生,记录两组患者的临床疗效、复发率、不良反应发生率和新生儿情况并进行对比分析。结果:两组患者经过治疗后,其外阴瘙痒、外阴灼痛和分泌物增多的症状均得到改善,且联合者患者改善得更显著(P<0.05);联合组患者的治疗总有效率为92.7%,明显高于单用组的67.2%,差异有统计学意义(P<0.05);治疗过程中,两组均有1例患者出现不良反应,但对病程影响不大,且两组患者均顺利分娩出健康新生儿。结论:克霉唑栓联合硝酸咪康唑霜治疗妊娠期外阴阴道念珠菌感染能够明显改善患者临床症状,不影响孕妇分娩和胎儿发育,安全性较高,在临床上值得推广。

Objectives： To explore the efficiency of different methods in the treatment of patients with vaginal Candida infection in pregnancy. Methods： 110 pregnant women with vaginal Candida infection treated in our hospital from October 2013 to October 2015 were chose and selected into two groups according to different therapy,each group with 55 patients. The single group were placed the clotrimazole in the vagina after rinsing the vagina with the baking soda solution every night,while the combination group were additionally treated with miconazole nitrate,all treated for a week. The clinical efficacy,recurrence rate,incidence of adverse reactions and neonatal status of the two groups were recorded and compared between the groups of patients. Results： The symptoms of pruritus vulvae,vulva burning secretions two groups of patients after treatment,the symptoms of the vulva urticant,vulva burning and increased secretion were improved,more significant improvement in the combination group（ P〈0. 05）. The total effective rate of the combination group was 92. 7%,which was significantly higher than that of the single use group,with statistically significant difference（ P〈0. 05）. In the course of treatment,there was one case of adverse event in two groups,but both had little effect on the course of the disease,and both successfully delivered a healthy newborn. Conclusion： The method of clotrimazole combined with nitric acid miconazole in the treatment of vulvovaginal Candida infection is effective,which can obviously improve the clinical symptoms and does not affect the pregnant women and fetal development,thusly worthy to be popularized in clinic.