血浆生长抑素、血管活性肠肽在单纯性肥胖患者中的表达及其与心理因素的关系

Expressions of plasma somatostatin and vasoactive intestinal peptide in patients with simple obesity and their correlations with mental factors

目的检测单纯性肥胖患者血浆SS、VIP表达水平,探讨血浆中SS、VIP水平与单纯性肥胖患者心理状况的关系。方法通过ELISA方法检测患者血浆SS、VIP的表达水平,分析SS、VIP的水平与肥胖伴心理疾患的关系。结果单纯性肥胖患者中,心理疾患者血浆SS、VIP水平显著低于心理正常者(P<0.05)。单纯性肥胖伴心理疾患者的SS表达与文化程度、宗教信仰、吸烟及饮酒史、VIP密切相关(P<0.05),VIP的表达与婚姻状况、SS表达密切相关(P<0.05)。多因素分析提示,体内SS、VIP水平的变化可作为独立的因素来预测肥胖患者的心理状况。结论血浆SS、VIP的表达与单纯性肥胖患者的心理因素密切相关。

Objective To detect the levels of plasma SS and VIP in patients with simple o- besity and explore the relationship between the expression level of SS and VIP and mental health. Methods The expressions of SS, VIP were detected by ELISA, and the relationship between mental disorders and the SS, VIP were analyzed. Results In patients with simple obesity, plasma SS, VIP levels in patients with mental disease were significantly lower than healthy people （ P 〈 0.05 ）. SS expression in simply obesity patients with mental disorders were closely related with cultural degree, religious belief, smoking and drinking history, expression of VIP （ P 〈 0.05 ）. VIP expression was closely related with marital status and SS expression （P 〈 0.05 ）. Multivariate analysis showed that changes of SS, VIP levels in vivo could be used as stand-alone predictors for psychological health of obese patients. Conclusion The expressions of SS and VIP are closely related with psychological factors in obese patients with mental disorders.