胰岛素泵餐前大剂量自动化输注的临床疗效观察

Clinical effect of large-dose automatical injection of premeal insulin using insulin pump

目的观察围术期2型糖尿病(DM2)住院患者应用胰岛素泵(CSII)餐前大剂量自动化输注的方便性、有效性和安全性。方法选取围术期2型糖尿病住院患者413例,根据随机数字表法分为自动化输注组207例和人工输注组206例,观察2组患者治疗后血糖达标时间、胰岛素用量、低血糖发生情况。结果 2组在缩短血糖达标时间、减少胰岛素用量、降低低血糖发生率上比较,差异无统计学意义(P>0.05);自动化输注组调泵时间短于对照组,人力成本低于人工输注组,差异有统计学意义(P<0.05)。结论胰岛素泵餐前大剂量自动化输注方法与餐前大剂量人工输注方法的有效性与安全性一致,但前者使用更方便,操作性更强,适于在基层医院推广运用。

Objective To observe convenience, effectiveness and safety of automatical injec- tion of premeal insulin using insulin pump （CSII）for hospitalized patients with type 2 diabetes（DM2）. Methods A total of 413 hospitalized patients with type 2 diabetes were randomly divided into auto- matical injection group with 207 cases and artificial infusion group with 206 cases, blood glucose control to target level, insulin dosage, hypoglycemia occurrence, incision healing after treatment were observed. Results No significant difference was seen in shortening time of blood glucose and reducing insulin dosage and the incidence of hypoglycemia in two groups （ P 〉 0.05 ）. The adjusting time of pump was shorter and labor costs was less in the automatical injection group than artificial infusion group and the difference was statistically significant（ P 〈 0.05 ）. Conclusion Efficacy and safety of two methods are almost the same, but automatical injection is more convenient, more practical, and suitable for promotion and application in primary hospitals compared with artificial infusion.