哮喘儿童血清1,25-二羟维生素D_3表达水平变化及其意义

Changes of serum 1,25-dihydroxy vitamin D_3 in children with bronchial asthma and their significance

目的探讨血清1,25-二羟维生素D3水平测定在儿童支气管哮喘治疗及预后的价值。方法采用酶联免疫吸附法(ELISA)分别测定142例不同严重程度哮喘患儿血清1,25-(OH)2D3值(分为轻、中、重3组),同时测定80例正常儿童血清1,25-(OH)2D3值。以上哮喘儿童经跟踪治疗1个月后,病情控制期时再测定以上指标,评价不同病程中受试儿童1,25-(OH)2D3水平变化的差异。结果重度组患儿血清1,25-(OH)2D3水平最低,正常儿童血清1,25-(OH)2D3水平最高,正常儿童及不同严重程度哮喘患儿血清1,25-(OH)2D3值差异均具有显著性(P<0.05)。142例患儿进入病情控制期后,不同控制情况患儿血清1,25-(OH)2D3水平差异显著(P<0.05),其中完全控制组血清1,25-(OH)2D3水平明显高于部分控制组及未控制组。结论哮喘儿童血清1,25-(OH)2D3处于低水平状态并与其病情严重程度及控制情况有关。因此,儿童哮喘血清1,25-二羟维生素D3表达水平的监测对预测病情程度、评价预后均有一定意义。

Objective To explore the value of determination of serum 1,25-dihydroxy vitamin D3 level in children with bronchial asthma and prognosis. Methods The value of 1, 25- （OH）2D3 of 142 children with different severity of asthma were determined by enzyme-linked immunosorbent （ELISA） and they were divided into light, medium and heavy groups, and level of 1, 25- （OH） 2D3 of 80 normal children were determined at the same time. After 1 month of treatment, the a- bove indexes were redetermined in disease control period. Results The level of serum 1,25-（OH） 2 D3 level in severe group was lowest, and highest in normal children, and there were significant differences in normal children and children with different severity of asthma （ P 〈 0.05 ） ; There were significant difference in 1, 25-（OH） 2D3 of 142 children after control period （P 〈 0.05 ）, and serum 1, 25-（ OH ）2 D3 level in completely controlled group was significantly higher than partly controlled group and uncontrolled group. Conclusion The level of serum 1, 25-（OH） 2 D3 is low in asthma children and is related to disease severity and control situation. Thus, monitoring level of serum 1,25- （OH） 2D3 in asthma children can predict disease condition and prognosis.