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老年类风湿关节炎外周血护骨素表达水平及对骨密度的影响 被引量:4

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摘要 目的 检测老年类风湿关节炎患者外周血护骨素(OPG)的表达水平并分析其与骨密度的相关性。方法 老年类风湿关节炎患者46例设为观察组,同期在我院健康体检的老年人46例为对照组。回顾性分析两组研究对象的临床资料,分析和比较两组骨密度以及OPG、核因子κB受体活化因子配基(RANKL)等血液学指标。结果 观察组患者OPG水平显著低于对照组(P〈0.01),而肿瘤坏死因子(TNF)-α及RANKL水平显著高于对照组(P〈0.01)。观察组患者前臂、大转子、股骨颈及L1~L4四个部位骨密度值均显著低于对照组(P〈0.01),观察组患者骨密度与OPG呈显著正相关(r=0.929,P〈0.01),而与TNF-α(r=-0.936,P〈0.01)及RANKL(r=-0.951,P〈0.01)呈显著负相关。结论 老年类风湿关节炎患者外周血低表达OPG而高表达促炎因子,这与其骨密度值降低密切相关,OPG有望成为改善此类患者骨质代谢的新靶点。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2016年第24期6216-6217,共2页 Chinese Journal of Gerontology
基金 国家自然科学基金青年科学基金项目(81301200) 江苏省中医药局科技项目(YB2015100)
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