沙利度胺联合柳氮磺胺吡啶治疗强直性脊柱炎

Thalidomide and salazosulfapyridine in treating ankylosing spondylitis

目的探讨沙利度胺联合柳氮磺胺吡啶治疗强直性脊柱炎的临床效果。方法将80例首诊强直性脊柱患者随机分为观察组和对照组,每组40例,观察组联合应用沙利度胺和柳氮磺胺吡啶,对照组单用沙利度胺。比较两组患者治疗后晨僵时间、扩胸度、强直脊柱炎病情活动指数、强直性脊柱炎功能指数、关节疼痛数、枕壁距、Schober试验以及ESR、CRP等指标,进行临床疗效评估。结果治疗后12周,两组患者各项指标均较用药前明显改善(P<0.05),观察组各项指标改善效果明显优于对照组(P<0.05),观察组总有效率高于对照组(P<0.05)。两组不良反应比较差异无统计学意义(P>0.05)。结论沙利度胺联合柳氮磺胺吡啶治疗强直性脊柱炎可以提高疗效,是一种较可靠的治疗方案。

Objective To investigate the clinical effects of thalidomide and salazosulfapyridine on ankylosing spondy-litis. Methods Eighty patients who had ankylosing spondylitis were randomly assigned observation group and control group, 40 cases in each group. The observation group patients were treated with thalidomide and salazosulfapyridine, the control group patients were treated with thalidomide. Morning stiffness duration, chest level, ankylosing spondyli-tis disease activity index, ankylosing spondylitis functional index, number of pain joint, index means to distance away from the pillow wall, Schober test and erythrocyte sedimentation rate, C-reactive protein were compared. The clinical effectiveness of each group was observed. Results Various indexs of each group patients were improved after treating 12 weeks （P〈0. 05）. The improvement effect of each index in observation group was better than control group （P〈0. 05）. Total effective rate of observation group was better than control group （P〈0. 05）. The adverse reactions of two groups were not significantly different （ P〉0. 05 ） . Conclusions Thalidomide and salazosulfapyridine can im-prove the ankylosing spondylitis treatment effect. It′s a reliable treatment method.