Nrf2/ARE信号通路及其在卵巢中的作用研究进展

Research Progress of Nrf2/ARE Pathway and It′s Role in Ovary

核因子E2相关因子2(nuclear factor erythroid-derived factor 2-related factor 2,Nrf2)是细胞自身抗氧化的关键因子,当发生氧化应激刺激时,Nrf2转移入核内,与抗氧化反应原件(antioxidant response element,ARE)结合,并调节下游多种抗氧化蛋白和解毒酶的表达,起到细胞内源性保护作用。Nrf2/ARE信号通路参与了多种疾病的病理生理过程,如炎症反应、呼吸系统疾病、心血管系统疾病和肿瘤等,但该通路在女性生殖系统尤其是卵巢组织中的研究较少。综述该通路的基本组成及调节,以及该通路在卵巢疾病,尤其是在卵巢衰老中的研究进展。

Nuclear factor erythroid-derived factor 2-related factor 2（Nrf2）is a key factor in anti-oxidation in most species.Once oxidative stress stimulus occurs,Nrf2 transfers into the nucleus,and binds to antioxidant response element（ARE）,and then regulates the expression of a variety of antioxdants and detoxifying enzymes to protect cells against oxidants injury.The Nrf2/ARE pathway involvs in the pathological process of many diseases,such as inflammation,respiratory disease,cardiovascular disease and tumor.But there is not enough research about its function in the female reproductive system,especially in ovary.In this article,we reviews the basic components of Nrf2/ARE pathway and its regulation,and the advanced study of this pathway in ovarian diseases,especially in ovarian aging.