蛋白质组学应用于早期妊娠流产的研究进展

Progress of Proteomics Applied to the Early Pregnancy Abortion

妊娠过程类似于半同种异体移植,母胎界面的功能失调与早期妊娠流产,如早期自然流产、复发性流产等有关,但具体发病机制仍不十分清楚。蛋白质组学是通过高通量、快速鉴定与定量分析细胞、组织、体液中的所有蛋白质组成、功能及蛋白之间的相互作用的学科,将蛋白质组学应用于早期妊娠流产病理机制研究,发现早期妊娠流产与胎盘滋养细胞的侵袭力不足、母胎界面血管形成异常、氧化应激、母胎界面免疫功能失调、凝血功能异常、肥胖等有关,有利于相关疾病的早期诊断。将蛋白质组学应用于不明原因复发性流产(URSA)的治疗研究,发现淋巴细胞主动免疫疗法可通过调整并恢复患者的免疫状态,从而维持妊娠,改善妊娠结局。综述蛋白质组学及其在早期妊娠流产中的应用。

Pregnancy is similar to semi allograft transplantation,the imbalance of the maternal-fetal interface coordination is closely related to early pregnancy abortion,such as：early spontaneous abortion,recurrent spontaneous abortion,but the pathogenesises are unclear.Proteomics is a scientific discipline which can analysis the composition,function and the relationship among proteins in cells,tissues,body fluids in a high flux,quickly identify,quantitative analytic way.The research that proteomics apply to early spontaneous abortion discovers that the pathogenesis relates to the superficial invasion of the trophocyte,the disfunction of the maternal-fetal vascular formation,oxidative stress,the maternal-fetal immune disfunction,the coagulation disorders,obesity and so on,it is benefit for early diagnosing.The research that proteomics apply to unexplained recurrent spontaneous abortion discovers that lymphocyte immunotherapy can maintain pregnancy and improve the outcomes of the pregnancy through improving the immune status.Now a review on proteomics and its application in early pregnancy abortion will be presented.