PARP3生物学功能研究进展

Research progress on biological function of PARP3

PARP3属于聚(ADP-核糖)聚合酶[Poly(ADP-ribose)polymerase,PARP]超家族,与PARP1、2有极高的同源性,均具有DNA依赖的ADP-核糖基团转移活性,但其在组织分布、生物学功能方面却又表现出极大不同。目前PARP1、2研究已较为深入,而PARP3的研究尚处于起步阶段,已有研究证明其可被双链断裂DNA及单链断裂哑铃型DNA所激活并对靶蛋白及自身进行MAR修饰,在DNA单链断裂、双链断裂、PARP1活化、神经系统和体液免疫等方面发挥作用,且与胶质瘤、乳腺癌存在相关性,但具体机制尚不明确。本文旨在从结构、活化、功能及与疾病的关系4个方面对PARP3的研究现状进行总结。

As a member of PARP superfamily,PARP3 shares a high homology with PARP1 and PARP2,which are all DNA-dependent enzymes that are catalytically activated by DNA strand breaks. Compared to PARP1 and PARP2,PARP3 exerted some special properties in tissue expression pattern and biological function. The evidence has shown that PARP3 could be activated by DNA double strand breaks and special DNA single strand breaks and synthesize mono（ ADP-ribose）（ MAR） covalently attached to target proteins including itself. PARP3 plays an important role in DNA double strand breaks,DNA single strand breaks,activation of PARP1 and development of nervous system. It has been reported that PARP3 is associated with glioma and breast cancers. In this review,PARP3 structure,activation mechanism,biological function and its relationship with diseases will be presented.