载脂蛋白A-I模拟肽的研究进展

Research advances on the apolipoptrotein A-I mimetic peptides

高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)由于其心血管保护作用而受到广泛的关注。研究发现,正常HDL在机体内起着逆转运胆固醇、抗炎、抗氧化和促进血管新生等保护心血管的功能。作为HDL含量最高的蛋白质,载脂蛋白A-I(apolipoptrotein A-I,apo A-I)在HDL的各种功能活动中起关键作用。根据apo A-I的两亲性α-螺旋结构特点,设计了一系列旨在模拟apo A-I功能的模拟肽。Apo A-I模拟肽的功能和代谢取决于它的氨基酸组成和序列,并被证实在心血管疾病、感染、炎症和氧化损伤、代谢综合征和肿瘤等疾病状态下发挥保护作用。部分临床试验肯定了apo A-I模拟肽的效益,但由于其高昂的成本而限制了它的实际应用。

High density lipoprotein cholesterol（ HDL-C） has received extensive attention because of its cardiovascular protective effects. Recent studies showed that HDL could promote reverse cholesterol transport（ RCT）, be anti-inflammatory and antioxidant, and induce angiogenesis.Apolipoptrotein A-I（ apo A-I）,the most abundant protein of HDL,plays a pivotal role in the HDL mediated-functional activities. Short peptides based on the amphiphilic alpha helix structure of apo A-I have been designed and aimed at imitating the function of apo A-I. The function and metabolism of these mimetic peptides depend on their amino acids component and sequence,and have been proved to exert protection in against cardiovascular disease,infection,inflammation and oxidative damage,metabolic syndrome and tumor. Clinical trials confirmed their benefits,but high cost put them out of the practical applications..