贝前列素对急性脑梗死患者凝血功能和神经功能的影响

Influence of beraprost on coagulation and neurological function in patients with acute cerebral infarction

目的探讨贝前列素对急性脑梗死患者凝血功能和神经功能影响的研究。方法选取复旦大学附属浦东医院神经内科脑梗死患者80例,随机分为2组:对照组40例,予临床常规治疗;实验组40例,与对照组相同的常规治疗基础上加用贝前列素治疗。观察2组患者治疗前后凝血功能和神经功能变化情况。结果与治疗前比较,治疗后2组患者的APTT、PT、Fib水平,血清NGF水平、Barthel评分均升高,D-二聚体(D-D)、血清NSE、S100β、NIHSS评分均降低;与对照组比较,实验组APTT、PT、Fib水平,血清NGF水平、Barthel评分、治疗总有效率均高于对照组;D-D、血清NSE、S100β、NIHSS评分均低于对照组,以上结果差异均有统计学意义(P<0.05)。结论贝前列素能有效减低急性脑梗死患者高凝状态,改善神经功能缺损程度,且具有较好的临床疗效。

Objective To study the effect of blood coagulation function and nerve function of beraprost in the treatment of acute cerebral infarction. Methods 80 cases of acute cerebral infarction were randomly divided into 2 groups,40 cases in the control group and 40 cases in the experiment group. The control group received routine treatment,the experiment group were treated with the same as the control group combined with beraprost. Changes of coagulation function and nerve function were compared pre-and post-treatment between two groups. Results Compared with pretreatment,APTT,PT,Fib level,serum NGF level,Barthel score increased post-treatment of the two groups,D-D,serum NSE,S100 b,NIHSS score decreased,compared with the control group,APTT,PT,Fib level,serum NGF level,Barthel score were higher in the experiment group,the total effective rate was higher than the control group,two D-D,serum NSE,S100β,NIHSS scores were lower than the control group,the differences were statistically significant（ P〈0. 05）. Conclusion Beraprost can reduce the high coagulation state in patients with acute cerebral infarction,improve the degree of neurological impairment,and has good clinical efficacy.