赖氨葡锌颗粒联合蒙脱石散和双歧杆菌乳杆菌三联活菌颗粒治疗小儿腹泻的效果

Effect of lysine hydrochloride and zinc gluconate granules combined with montmorillonite powder and live combined bifidobacterium and lactobacillus granules in infantile diarrhea

目的评估赖氨葡锌颗粒联合蒙脱石散和双歧杆菌乳杆菌三联活菌颗粒治疗小儿腹泻的效果。方法选取宁波大学医学院附属医院2014年5月~2016年5月收治的小儿腹泻患儿80例,将这些患儿随机分为联合治疗组（赖氨葡锌颗粒联合蒙脱石散和双歧杆菌乳杆菌三联活菌颗粒）和常规治疗组（蒙脱石散和双歧杆菌乳杆菌三联活菌颗粒）2组,每组40例,对2组患儿的临床疗效、不良反应发生情况、大便频率恢复正常时间、大便性状恢复正常时间、腹痛消失时间、体温恢复正常时间、呕吐消失时间进行统计分析。结果联合治疗组患儿治疗的总有效率97.5%（39/40）显著高于常规治疗组的72.5%（29/40）,差异有统计学意义（P〈0.05）,大便频率恢复正常时间、大便性状恢复正常时间、腹痛消失时间、体温恢复正常时间、呕吐消失时间均显著短于常规治疗组,差异有统计学意义（P〈0.05）。结论赖氨葡锌颗粒联合蒙脱石散和双歧杆菌乳杆菌三联活菌颗粒治疗小儿腹泻的效果较蒙脱石散和双歧杆菌乳杆菌三联活菌颗粒常规治疗好。

Objective To evaluate the effect of lysine hydrochloride and zinc gluconate granules combined with montmorillonite powder and live combined bifidobacterium and lactobacillus granules in the treatment of infantile diarrhea. Methods 80 cases of children with infantile diarrhea in our hospital from May 2014 to May 2016 were selected and randomly divided into the combined treatment group（ lysine hydrochloride and zinc gluconate granules combined with montmorillonite powder and live combined bifidobacterium and lactobacillus granules）,and conventional treatment group（ montmorillonite powder and live combined bifidobacterium and lactobacillus granules） two groups with 40 cases in each group,the clinical curative effects,adverse reactions,stool frequency recovery normal time,stool normal time,abdominal pain disappeared time,temperature recovery time,vomiting disappeared time of the two groups were statistically analyzed. Results The total treatment effective rate of the combined treatment group 97. 5%（ 39 /40） was significantly higher than the conventional treatment group 72. 5%（ 29 /40）,the difference was statistically significant（ P〈0. 05）,the stool frequency recovery normal time,stool normal time,abdominal pain disappeared time,temperature recovery time,vomiting disappeared time were significantly shorter than the conventional treatment group,the difference was statistically significant（ P〈0. 05）. Conclusion The effect of lysine hydrochloride and zinc gluconate granules combined with montmorillonite powder and live combined bifidobacterium and lactobacillus granules in the treatment of infantile diarrhea is better than montmorillonite powder and live combined bifidobacterium and lactobacillus granules.