幽门螺杆菌感染与短暂性脑缺血发作的相关性研究

Study on the Association between Helicobacter Pylori Infection and Tran-sient Ischemia Attack.

目的探讨幽门螺杆菌(Hp)感染与短暂性脑缺血发作(TIA)的关系及抗Hp治疗对TIA预后的影响。方法随机选择2014年1—12月在该院发病1周内的TIA患者(56例)与健康体检者(50名),检测血清Hp抗体。Hp阳性的TIA患者随机分为抗Hp治疗组(20例)和常规治疗组(19例)。抗Hp治疗组给予根除Hp治疗并随访1年,观察终点事件的发生。结果 TIA组Hp感染率显著高于正常对照组(69.64%vs 48.00%,χ2=5.21,P<0.01);抗Hp治疗组TIA复发率显著低于对照组(5.00%vs 26.32%,χ2=4.02,P<0.05);抗Hp治疗组急性脑梗死发生率显著低于对照组(0%vs15.79%,χ2=4.56,P<0.05)。结论 Hp感染与TIA相关;抗Hp治疗可显著降低TIA患者复发率,减少缺血性脑卒中的发生。

Objective To investigate the association between helicobacter pylori（Hp） infection and transient ischemia attack（TIA）. Methods Random selection Fifty-sixpations with TIA in our hospital from January to December 2014 were enrolled in the study and 50 individuals as controls,Hp antibodies were determined.Hp positive TIA patient were randomly divided into towgroups,one of which was treated to eradicate Hp（20 cases）,while the other was normal treated as a control group（19cases）. Anti Hp treatment group given Hperadication therapy and follow-up of 1 year,Observe the end events. Results The positive rate for Hp-Ig G in TIA patients was significantly higher than that of control（69.64% vs 48.00%,χ2=5.21,P0.01）.The recurrence rate of TIA in treated group was significantly lower than that of contrals（5.00% vs 26.32%,χ2=4.02,P0.05）.The incidence rate of acute cerebral infarction in treated group was significantly lower than that of controls（0% vs 15.79%,χ2=4.56,P0.05）. Conclusion Hp infection is closely associated with transient ischemia attack.The eradication of Hp can effective improves the prognosis in pations with TIA.