40例使用替加环素的临床用药分析

Analysis of Clinical Use of Tigecycline in 40 Cases

目的评价使用替加环素的住院患者临床用药情况。方法采用回顾性研究方法,收集浙江省丽水市中心医院2012年1月-2014年12月使用替加环素住院患者的临床资料(基础疾病、细菌学培养结果、联合用药、疗效、不良反应发生情况等),共40例,并对其应用进行合理性评价。结果该院近3年使用替加环素患者的抗感染治疗有效率为42.5%,合理使用率17.5%,基本合理使用率77.5%,不合理使用率5.0%,出现不良反应6例(15.0%)。结论该院住院患者替加环素的使用基本合理;替加环素对各类敏感菌引起的感染临床疗效较好,但不良反应发生率较高,临床应用过程中应引起关注。

Objective To evaluate clinical use of tigecycline in hospital patients. Methods Basic diseases,pathologic examinations,concurrent medication,therapeutic efficacy and side effects of 40 patients in Lishui Central Hospital of Zhejiang Province from January 2012 to December 2014 were analyzed retrospectively. Results The effective rate of patients using tigecycline for anti-infection treatment in hospital was 42. 5%. The rates of rational use,basically rational use and irrational use were 17. 5%,77. 5% and 5. 0%,respectively. Adverse drug reactions occurred in 6 cases of tigecycline use（ 15. 0%）. Conclusion Clinical use of tigecycline in inpatients was basically reasonable in this hospital. The clinical curative effect of tigecycline was good in a variety of infections caused by sensitive bacteria. However,the incidence of adverse drug reactions was high. Attentions should be paid in clinical application.