摘要
聚合物刷是由一端紧密接枝在一个曲面或平面的聚合物链组成的大分子结构。近年来,随着聚合物制备方法和表面修饰技术的不断发展,聚合物刷的应用范围也在不断拓宽,相关研究已成为功能高分子材料领域的热点之一。具有特殊结构和功能的聚合物刷在生物分子固定、蛋白质分离、酶催化、药物控释等方面具有广阔的应用前景。本文综述了聚合物刷与生物分子相互作用及应用的最新研究进展,并展望了今后的发展方向。
Polymer brush is a structure with polymer chains attached with one end to a curved or planar surface. In recent years, with the development of polymer preparation methods and surface modification technology, the application range of polymer brush is continuously expanded. Relevant researches of polymer brush become one of the hotpots in the area of functional polymeric materials. Polymer brushes with unique structure and surface properties become suitable candidates in the application of biomolecule immobilization,protein separation, enzymatic catalyst and controlled drug delivery. In this review,the latest progress in interactions between polymer brushes and biomolecules is systematically described, and some possible directions for further research are forecasted.
作者
王思怿
郭旭虹
陈凯敏
WANG Si-yi GUO Xu - hong CHEN Kai-min(Testing Center,Shanghai Research Institute of Chemical Industry,Shanghai 200062,China State Key Laboratory of Chemical Engineering, School of Chemical Engineering,East China University of Science and Technology,Shanghai 200237,China College of Chemistry and Chemical Engineering,Shanghai University of Engineering Science,Shanghai 201620,China)
出处
《功能高分子学报》
CAS
CSCD
北大核心
2016年第4期359-376,共18页
Journal of Functional Polymers
基金
国家自然科学基金(21504052)
上海市青年科技英才扬帆计划(15YF1404800)
关键词
聚合物刷
生物分子
相互作用
蛋白固定化
酶催化
polymer brush
biomolecule
interaction
protein immobilization
enzymatic catalyst