自噬在急性淋巴细胞白血病中的作用

Role of Autophagy in Acute Lymphoblastic Leukemia

自噬是一个进化上高度保守的溶酶体降解途径,与急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)的发生、发展、治疗、耐药、复发等过程密切相关。在急性淋巴细胞白血病中,自噬是充当化疗耐药机制还是起着肿瘤抑制功能的作用,主要取决于细胞自噬所处的环境。明确不同治疗条件下自噬对ALL的不同作用,了解各种自噬信号通路,靶向联合自噬诱导剂或自噬抑制剂,将对ALL的治疗具有重要意义,尤其是有利于难治性复发患者的治疗。本文就自噬对ALL中的发生发展、耐药机制及治疗中的作用做一综述,为ALL治疗开发靶向自噬的新药提供一定的理论指导。

Autophagy is an evolutionarily highly conservative lysosomal degradative process and closely associates with pathogenesis,process,treatment,drug resistance and relapse of acute lymphoblastic leukemia（ALL）.Whether the autophagy displays resistance to chemotherapy or a tumor suppressor in ALL,it mainly depends on the context of autophagy in the cells.Understanding the different role of autophagy in different conditions for ALL,determing the autophagy signaling pathways and targeting combination with autophagy revulsants or inhibitors were significant for the therapy of ALL,particularly for the treatment of refractory/relapsed ALL patients.This review summarizes the role of autophagy in pathogenesis,developmant,drug resistance and treatment of ALL,providing some theoretical guidance of new drugs targeting autophagy for ALL therapy.