清胃散火汤联合常规根管加抗生素疗法治疗牙周-牙髓联合病变临床研究

Study of effect of Qingwei-Sanhuo decoction combined with routine root canal plus antibiotic therapy on the patients with periodontal-endodontic lesions

目的 评价清胃散火汤联合常规根管加抗生素疗法治疗牙周-牙髓联合病变的临床疗效.方法 将符合入选标准的牙周-牙髓联合病变患者168例,采用随机数字表法分为2组,每组84人.对照组进行常规根管加抗生素消炎治疗,观察组在对照组基础上加服清胃散火汤.2组均治疗30 d.观察牙龈指数（gingiva index,GI）、菌斑指数（plaque index,PLI）、探诊深度（probing depth,PD）、龈沟出血指数（sulcular bleeding index,SBI）变化,评价临床疗效.结果 观察组总有效率为96.4%（81/84）、对照组为78.6%（66/84）,2组比较差异有统计学意义（χ2=26.435,P=0.014）.治疗后,观察组PD[（3.29±0.76）mm比（4.95±1.02）mm,t=3.796]、GI[（1.02±0.31）比（1.96±0.63）,t=2.983]、SBI[（3.62±0.89）比（4.66±1.01）,t=3.424]、PLI[（1.23±0.42）比（1.88±0.81）,t=6.897]均低于对照组（P〈0.05）.结论 清胃散火汤联合常规根管加抗生素治疗可降低牙周-牙髓联合病变患者的牙周指数,提高临床疗效.

Objective To evaluate the effect of Qingwei-Sanhuo decoction combined with routine root canal plus antibiotic therapy for the periodontal and pulpal lesions.Methods A total of 168 patients with periodontal - pulpal disease were randomly divided into two groups, 84 patients in each group. The control group was treated with conventional root canal plus antibiotic anti-inflammatory treatment. The observation group was treated withQingwei-Sanhuo decoction based on the control group. Both groups were treated 30 days. The changes of gingival index （GI）, plaque index （PLI）, probing depth （PD） and sulcular bleeding index （SBI） were assessed.Results The total effect rate was 96.4% （81/84） in the observation group and 78.6% （66/84） in the control group. There was significant difference between the two groups （χ2=26.435,P=0.014）. After treatment, the PD （3.29 ± 0.76 mmvs. 4.95 ± 1.02 mm,t=3.796）, GI （1.02 ± 0.31vs.1.96 ± 0.63,t=2.983）, SBI （3.62 ± 0.89vs. 4.66 ± 1.01,t=3.424）, PLI （2.23 ± 0.42vs. 3.88 ± 0.81,t=6.897） in the observation group were significantly lower than those in the control group （P〈0.05）. Conclusions The Qingwei-Sanhuo decoction combined with routine root canal plus antibiotic therapy can reduce the periodontal index of patients with periodontal - pulp disease, and improve the clinical curative effect.